STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A316Z3V3Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (168 aa)    
Predicted Functional Partners:
URM1
Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...]
   
 0.961
A0A316ZA70
Thioredoxin.
   
 0.921
A0A316Z6Y9
Thioredoxin-like protein.
   
 0.881
A0A316Z488
Uncharacterized protein.
   
 0.854
A0A316ZII9
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
   
 0.802
A0A316ZE93
Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
    
 0.729
A0A316ZE47
Protein disulfide-isomerase.
   
 0.717
A0A316YZ59
Thioredoxin-domain-containing protein.
    
 0.715
A0A316Z5V4
Thioredoxin-domain-containing protein; Belongs to the protein disulfide isomerase family.
    
 0.715
A0A316Z6L1
Thioredoxin domain-containing protein.
    
 0.715
Your Current Organism:
Tilletiopsis washingtonensis
NCBI taxonomy Id: 58919
Other names: ATCC 36489, CBS 544.50, JCM 8362, T. washingtonensis
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