ALA1 protein (Tilletiopsis washingtonensis) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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ALA1

Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (989 aa)

Predicted Functional Partners:

A0A316ZFR6

0.925

A0A316Z6E4

0.924

A0A316ZHB6

0.920

A0A316ZI76

0.920

A0A316Z248

0.916

A0A316Z5Y0

0.907

A0A316Z9Q1

0.890

A0A316Z7S5

0.860

A0A316Z6Z8

0.842

A0A316Z916

0.814

Your Current Organism:

Tilletiopsis washingtonensis

NCBI taxonomy Id: 58919
Other names: ATCC 36489, CBS 544.50, JCM 8362, T. washingtonensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A316Z248	A0A316Z5Y0	A0A316Z248	A0A316Z5Y0	Anaphase-promoting complex, subunit 10.	RING-type domain-containing protein.	0.999
A0A316Z248	A0A316Z6E4	A0A316Z248	A0A316Z6E4	Anaphase-promoting complex, subunit 10.	ANAPC4 domain-containing protein.	0.999
A0A316Z248	A0A316Z9Q1	A0A316Z248	A0A316Z9Q1	Anaphase-promoting complex, subunit 10.	Uncharacterized protein.	0.988
A0A316Z248	A0A316ZFR6	A0A316Z248	A0A316ZFR6	Anaphase-promoting complex, subunit 10.	TPR-like protein.	0.999
A0A316Z248	A0A316ZHB6	A0A316Z248	A0A316ZHB6	Anaphase-promoting complex, subunit 10.	ANAPC5 domain-containing protein.	0.999
A0A316Z248	A0A316ZI76	A0A316Z248	A0A316ZI76	Anaphase-promoting complex, subunit 10.	Uncharacterized protein.	0.999
A0A316Z248	ALA1	A0A316Z248	A0A316ZHK3	Anaphase-promoting complex, subunit 10.	Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.	0.916
A0A316Z5Y0	A0A316Z248	A0A316Z5Y0	A0A316Z248	RING-type domain-containing protein.	Anaphase-promoting complex, subunit 10.	0.999
A0A316Z5Y0	A0A316Z6E4	A0A316Z5Y0	A0A316Z6E4	RING-type domain-containing protein.	ANAPC4 domain-containing protein.	0.999
A0A316Z5Y0	A0A316Z9Q1	A0A316Z5Y0	A0A316Z9Q1	RING-type domain-containing protein.	Uncharacterized protein.	0.968
A0A316Z5Y0	A0A316ZFR6	A0A316Z5Y0	A0A316ZFR6	RING-type domain-containing protein.	TPR-like protein.	0.999
A0A316Z5Y0	A0A316ZHB6	A0A316Z5Y0	A0A316ZHB6	RING-type domain-containing protein.	ANAPC5 domain-containing protein.	0.999
A0A316Z5Y0	A0A316ZI76	A0A316Z5Y0	A0A316ZI76	RING-type domain-containing protein.	Uncharacterized protein.	0.999
A0A316Z5Y0	ALA1	A0A316Z5Y0	A0A316ZHK3	RING-type domain-containing protein.	Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.	0.907
A0A316Z6E4	A0A316Z248	A0A316Z6E4	A0A316Z248	ANAPC4 domain-containing protein.	Anaphase-promoting complex, subunit 10.	0.999
A0A316Z6E4	A0A316Z5Y0	A0A316Z6E4	A0A316Z5Y0	ANAPC4 domain-containing protein.	RING-type domain-containing protein.	0.999
A0A316Z6E4	A0A316Z9Q1	A0A316Z6E4	A0A316Z9Q1	ANAPC4 domain-containing protein.	Uncharacterized protein.	0.983
A0A316Z6E4	A0A316ZFR6	A0A316Z6E4	A0A316ZFR6	ANAPC4 domain-containing protein.	TPR-like protein.	0.999
A0A316Z6E4	A0A316ZHB6	A0A316Z6E4	A0A316ZHB6	ANAPC4 domain-containing protein.	ANAPC5 domain-containing protein.	0.999
A0A316Z6E4	A0A316ZI76	A0A316Z6E4	A0A316ZI76	ANAPC4 domain-containing protein.	Uncharacterized protein.	0.999

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.889

expected number of edges:

13

PPI enrichment p-value:

6.25e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009132

Nucleoside diphosphate metabolic process

7 of 58

2.45

6.02

4.55e-13

GO:0072528

Pyrimidine-containing compound biosynthetic process

5 of 28

2.62

4.81

5.53e-10

GO:0009142

Nucleoside triphosphate biosynthetic process

5 of 29

2.6

4.78

6.02e-10

GO:0009141

Nucleoside triphosphate metabolic process

6 of 73

2.28

4.67

1.67e-10

GO:0090407

Organophosphate biosynthetic process

9 of 281

1.87

4.45

4.55e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

6 of 25

2.74

6.13

1.82e-12

GO:0019205

Nucleobase-containing compound kinase activity

6 of 29

2.68

6.04

2.01e-12

GO:0004550

Nucleoside diphosphate kinase activity

3 of 4

3.24

3.23

1.41e-06

GO:0004017

Adenylate kinase activity

3 of 4

3.24

3.23

1.41e-06

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 765

1.32

1.68

2.39e-06

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36277867

(2022) Cold-induced denaturation of muscle proteins in hairtail (Trichiurus lepturus) during storage: Physicochemical and label-free based proteomics analyses.

3 of 52

2.12

1.26

0.0040

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5678

Purine metabolism

9 of 40

2.72

9.69

3.16e-20

CL:5732

Mixed, incl. CTP metabolic process, and Adenylate kinase activity

7 of 13

3.09

9.1

9.18e-18

CL:5673

Mixed, incl. Purine metabolism, and Metabolism of nucleotides

10 of 157

2.17

7.13

1.42e-18

CL:5748

Adenylate kinase activity, and ATP cone domain

4 of 5

3.27

4.99

8.16e-10

CL:5734

Nucleoside diphosphate kinase, and Purine ribonucleoside bisphosphate metabolic process

2 of 5

2.97

1.63

0.0011

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pvm00230

Purine metabolism

9 of 76

2.44

8.5

2.35e-19

pvm00730

Thiamine metabolism

5 of 10

3.06

6.48

9.96e-13

pvm00240

Pyrimidine metabolism

5 of 36

2.51

5.02

1.24e-10

pvm00983

Drug metabolism - other enzymes

4 of 49

2.28

3.42

1.40e-07

pvm01100

Metabolic pathways

10 of 991

1.37

2.44

3.87e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-499943

Interconversion of nucleotide di- and triphosphates

5 of 21

2.74

4.93

4.73e-10

MAP-15869

Metabolism of nucleotides

6 of 104

2.12

4.02

1.80e-09

MAP-1430728

Metabolism

7 of 2301

0.85

0.61

0.0055

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

7 of 411

1.59

2.59

2.75e-08

KW-0547

Nucleotide-binding

6 of 685

1.31

1.48

2.31e-05

KW-0067

ATP-binding

5 of 552

1.32

1.33

0.00015

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13207

AAA domain

3 of 5

3.14

2.93

4.83e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR034907

Nucleoside diphosphate kinase-like domain

3 of 3

3.36

2.93

5.10e-06

IPR001564

Nucleoside diphosphate kinase

3 of 3

3.36

2.93

5.10e-06

IPR036850

Nucleoside diphosphate kinase-like domain superfamily

3 of 5

3.14

2.92

5.10e-06

IPR033690

Adenylate kinase, conserved site

3 of 5

3.14

2.92

5.10e-06

IPR000850

Adenylate kinase/UMP-CMP kinase

3 of 6

3.06

2.91

5.10e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00562

These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.

3 of 3

3.36

3.43

6.44e-07

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