ADH85102.1 protein (Desulfurivibrio alkaliphilus)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

ADH85102.1

KEGG: gur:Gura_1996 cytochrome c family protein; TIGRFAM: cytochrome C family protein; PFAM: doubled CXXCH domain protein. (401 aa)

Predicted Functional Partners:

ADH85104.1

0.946

ADH85101.1

0.931

ADH85097.1

0.909

ADH85099.1

0.890

ADH85103.1

0.838

ADH85094.1

0.820

ADH85106.1

0.778

ADH85105.1

0.773

ADH85107.1

0.773

ADH85457.1

0.771

Your Current Organism:

Desulfurivibrio alkaliphilus

NCBI taxonomy Id: 589865
Other names: D. alkaliphilus AHT 2, Desulfurivibrio alkaliphilus AHT 2, Desulfurivibrio alkaliphilus str. AHT 2, Desulfurivibrio alkaliphilus strain AHT 2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH85094.1	ADH85097.1	DaAHT2_0388	DaAHT2_0391	PFAM: histidine kinase HAMP region domain protein; KEGG: dal:Dalk_0432 putative methyl-accepting chemotaxis sensory transducer.	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	0.739
ADH85094.1	ADH85099.1	DaAHT2_0388	DaAHT2_0393	PFAM: histidine kinase HAMP region domain protein; KEGG: dal:Dalk_0432 putative methyl-accepting chemotaxis sensory transducer.	KEGG: mac:MA1904 hypothetical protein.	0.819
ADH85094.1	ADH85101.1	DaAHT2_0388	DaAHT2_0395	PFAM: histidine kinase HAMP region domain protein; KEGG: dal:Dalk_0432 putative methyl-accepting chemotaxis sensory transducer.	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	0.800
ADH85094.1	ADH85102.1	DaAHT2_0388	DaAHT2_0396	PFAM: histidine kinase HAMP region domain protein; KEGG: dal:Dalk_0432 putative methyl-accepting chemotaxis sensory transducer.	KEGG: gur:Gura_1996 cytochrome c family protein; TIGRFAM: cytochrome C family protein; PFAM: doubled CXXCH domain protein.	0.820
ADH85094.1	ADH85103.1	DaAHT2_0388	DaAHT2_0397	PFAM: histidine kinase HAMP region domain protein; KEGG: dal:Dalk_0432 putative methyl-accepting chemotaxis sensory transducer.	KEGG: gbm:Gbem_1124 cytochrome c family protein; TIGRFAM: cytochrome C family protein; PFAM: doubled CXXCH domain protein.	0.816
ADH85094.1	ADH85104.1	DaAHT2_0388	DaAHT2_0398	PFAM: histidine kinase HAMP region domain protein; KEGG: dal:Dalk_0432 putative methyl-accepting chemotaxis sensory transducer.	KEGG: tye:THEYE_A1221 foldase protein PrsA 1, putative.	0.820
ADH85094.1	ADH85457.1	DaAHT2_0388	DaAHT2_0753	PFAM: histidine kinase HAMP region domain protein; KEGG: dal:Dalk_0432 putative methyl-accepting chemotaxis sensory transducer.	PFAM: NHL repeat containing protein; KEGG: ade:Adeh_3066 NHL repeat-containing protein.	0.515
ADH85097.1	ADH85094.1	DaAHT2_0391	DaAHT2_0388	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	PFAM: histidine kinase HAMP region domain protein; KEGG: dal:Dalk_0432 putative methyl-accepting chemotaxis sensory transducer.	0.739
ADH85097.1	ADH85099.1	DaAHT2_0391	DaAHT2_0393	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	KEGG: mac:MA1904 hypothetical protein.	0.855
ADH85097.1	ADH85101.1	DaAHT2_0391	DaAHT2_0395	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	0.798
ADH85097.1	ADH85102.1	DaAHT2_0391	DaAHT2_0396	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	KEGG: gur:Gura_1996 cytochrome c family protein; TIGRFAM: cytochrome C family protein; PFAM: doubled CXXCH domain protein.	0.909
ADH85097.1	ADH85103.1	DaAHT2_0391	DaAHT2_0397	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	KEGG: gbm:Gbem_1124 cytochrome c family protein; TIGRFAM: cytochrome C family protein; PFAM: doubled CXXCH domain protein.	0.912
ADH85097.1	ADH85104.1	DaAHT2_0391	DaAHT2_0398	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	KEGG: tye:THEYE_A1221 foldase protein PrsA 1, putative.	0.911
ADH85097.1	ADH85105.1	DaAHT2_0391	DaAHT2_0399	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	KEGG: gsu:GSU2497 putative lipoprotein.	0.641
ADH85097.1	ADH85106.1	DaAHT2_0391	DaAHT2_0400	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	KEGG: ank:AnaeK_3168 lipoprotein, putative.	0.641
ADH85097.1	ADH85107.1	DaAHT2_0391	DaAHT2_0401	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	KEGG: geo:Geob_3163 hypothetical protein.	0.641
ADH85097.1	ADH85457.1	DaAHT2_0391	DaAHT2_0753	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	PFAM: NHL repeat containing protein; KEGG: ade:Adeh_3066 NHL repeat-containing protein.	0.786
ADH85099.1	ADH85094.1	DaAHT2_0393	DaAHT2_0388	KEGG: mac:MA1904 hypothetical protein.	PFAM: histidine kinase HAMP region domain protein; KEGG: dal:Dalk_0432 putative methyl-accepting chemotaxis sensory transducer.	0.819
ADH85099.1	ADH85097.1	DaAHT2_0393	DaAHT2_0391	KEGG: mac:MA1904 hypothetical protein.	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	0.855
ADH85099.1	ADH85101.1	DaAHT2_0393	DaAHT2_0395	KEGG: mac:MA1904 hypothetical protein.	PFAM: NHL repeat containing protein; KEGG: hypothetical protein.	0.859

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

16

PPI enrichment p-value:

1.33e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042273

Ribosomal large subunit biogenesis

10 of 77

1.98

5.59

4.57e-16

GO:0000470

Maturation of LSU-rRNA

7 of 41

2.09

4.54

4.47e-11

GO:0000463

Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

6 of 30

2.16

4.16

1.09e-09

GO:0042254

Ribosome biogenesis

11 of 274

1.47

2.94

1.49e-13

GO:0006364

rRNA processing

9 of 204

1.51

2.73

1.85e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043021

Ribonucleoprotein complex binding

3 of 41

1.73

0.75

0.0338

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030687

Preribosome, large subunit precursor

9 of 35

2.27

7.01

7.92e-17

GO:0005730

Nucleolus

11 of 215

1.57

3.56

2.69e-15

GO:0005654

Nucleoplasm

4 of 211

1.14

0.77

0.0085

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4695

Preribosome, large subunit precursor, and Ribosomal large subunit export from nucleus

10 of 28

2.42

8.78

2.32e-20

CL:4698

Preribosome, large subunit precursor, and ATPase binding

9 of 21

2.49

8.61

4.01e-19

CL:4684

Preribosome, large subunit precursor, and DEAD/DEAH box helicase domain

11 of 63

2.1

7.28

2.32e-20

CL:4723

Mixed, incl. Circularly permuted (CP)-type guanine nucleotide-binding (G) domain, and ATPase binding

3 of 6

2.56

2.59

1.45e-05

CL:4700

Maturation of LSU-rRNA, and PUA domain

3 of 10

2.34

2.27

4.62e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

6 of 134

1.51

1.86

9.99e-06

MAP-8868773

rRNA processing in the nucleus and cytosol

6 of 138

1.5

1.84

9.99e-06

MAP-72312

rRNA processing

6 of 141

1.49

1.83

9.99e-06

MAP-8953854

Metabolism of RNA

7 of 553

0.96

0.85

0.00046

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030687

Preribosome, large subunit precursor

3 of 22

2.0

1.6

0.00067

GOCC:0031981

Nuclear lumen

8 of 457

1.11

1.2

1.58e-05

GOCC:0005730

Nucleolus

3 of 98

1.35

0.67

0.0345

GOCC:0005634

Nucleus

9 of 1134

0.76

0.66

0.00023

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0690

Ribosome biogenesis

4 of 18

2.21

2.77

3.05e-06

KW-0698

rRNA processing

3 of 17

2.11

1.85

0.00024

KW-0539

Nucleus

5 of 273

1.13

0.94

0.0014

KW-0489

Methyltransferase

2 of 30

1.69

0.69

0.0458

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030378

Circularly permuted (CP)-type guanine nucleotide-binding (G) domain

2 of 2

2.86

0.89

0.0247

IPR023179

GTP-binding protein, orthogonal bundle domain superfamily

2 of 3

2.69

0.89

0.0247

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