STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADH85849.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (453 aa)    
Predicted Functional Partners:
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
 0.951
dnaA
Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
 
 
 
 0.891
ADH84786.1
KEGG: dps:DP2579 single-strand binding protein (ssb); TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n.
 
 0.823
rplI
Ribosomal protein L9; Binds to the 23S rRNA.
  
  
 0.812
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.765
ADH86218.1
KEGG: maq:Maqu_2217 IstB ATP binding domain-containing protein; PFAM: IstB domain protein ATP-binding protein; SMART: AAA ATPase.
  
 
 0.747
ADH86755.1
KEGG: maq:Maqu_2217 IstB ATP binding domain-containing protein; PFAM: IstB domain protein ATP-binding protein; SMART: AAA ATPase.
  
 
 0.747
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
  
 0.733
rpsR
Ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family.
 
    0.657
ADH85847.1
PFAM: Protein of unknown function DUF2232, membrane; KEGG: dps:DP2597 hypothetical protein.
       0.628
Your Current Organism:
Desulfurivibrio alkaliphilus
NCBI taxonomy Id: 589865
Other names: D. alkaliphilus AHT 2, Desulfurivibrio alkaliphilus AHT 2, Desulfurivibrio alkaliphilus str. AHT 2, Desulfurivibrio alkaliphilus strain AHT 2
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