ADH86074.1 protein (Desulfurivibrio alkaliphilus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ADH86074.1

PFAM: UspA domain protein; KEGG: dol:Dole_1866 UspA domain-containing protein. (318 aa)

Predicted Functional Partners:

ADH85295.1

0.737

ADH86642.1

0.680

ADH85262.1

0.663

ADH86739.1

0.661

ADH86612.1

0.599

ADH86670.1

0.584

ADH87316.1

0.582

ADH85444.1

0.558

ADH86885.1

0.544

ADH87270.1

0.541

Your Current Organism:

Desulfurivibrio alkaliphilus

NCBI taxonomy Id: 589865
Other names: D. alkaliphilus AHT 2, Desulfurivibrio alkaliphilus AHT 2, Desulfurivibrio alkaliphilus str. AHT 2, Desulfurivibrio alkaliphilus strain AHT 2

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH85262.1	ADH85295.1	DaAHT2_0556	DaAHT2_0589	KEGG: dps:DP2176 hypothetical protein.	PFAM: protein of unknown function DUF181; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; KEGG: dps:DP1955 hypothetical protein.	0.752
ADH85262.1	ADH86074.1	DaAHT2_0556	DaAHT2_1379	KEGG: dps:DP2176 hypothetical protein.	PFAM: UspA domain protein; KEGG: dol:Dole_1866 UspA domain-containing protein.	0.663
ADH85262.1	ADH86612.1	DaAHT2_0556	DaAHT2_1932	KEGG: dps:DP2176 hypothetical protein.	KEGG: dps:DP2929 hypothetical protein.	0.690
ADH85262.1	ADH86642.1	DaAHT2_0556	DaAHT2_1964	KEGG: dps:DP2176 hypothetical protein.	KEGG: dps:DP0127 hypothetical protein.	0.760
ADH85262.1	ADH86670.1	DaAHT2_0556	DaAHT2_1992	KEGG: dps:DP2176 hypothetical protein.	KEGG: dps:DP0753 hypothetical protein.	0.749
ADH85262.1	ADH86739.1	DaAHT2_0556	DaAHT2_2066	KEGG: dps:DP2176 hypothetical protein.	KEGG: dal:Dalk_2376 hypothetical protein.	0.677
ADH85295.1	ADH85262.1	DaAHT2_0589	DaAHT2_0556	PFAM: protein of unknown function DUF181; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; KEGG: dps:DP1955 hypothetical protein.	KEGG: dps:DP2176 hypothetical protein.	0.752
ADH85295.1	ADH86074.1	DaAHT2_0589	DaAHT2_1379	PFAM: protein of unknown function DUF181; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; KEGG: dps:DP1955 hypothetical protein.	PFAM: UspA domain protein; KEGG: dol:Dole_1866 UspA domain-containing protein.	0.737
ADH85295.1	ADH86612.1	DaAHT2_0589	DaAHT2_1932	PFAM: protein of unknown function DUF181; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; KEGG: dps:DP1955 hypothetical protein.	KEGG: dps:DP2929 hypothetical protein.	0.763
ADH85295.1	ADH86642.1	DaAHT2_0589	DaAHT2_1964	PFAM: protein of unknown function DUF181; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; KEGG: dps:DP1955 hypothetical protein.	KEGG: dps:DP0127 hypothetical protein.	0.773
ADH85295.1	ADH86670.1	DaAHT2_0589	DaAHT2_1992	PFAM: protein of unknown function DUF181; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; KEGG: dps:DP1955 hypothetical protein.	KEGG: dps:DP0753 hypothetical protein.	0.733
ADH85295.1	ADH86739.1	DaAHT2_0589	DaAHT2_2066	PFAM: protein of unknown function DUF181; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; KEGG: dps:DP1955 hypothetical protein.	KEGG: dal:Dalk_2376 hypothetical protein.	0.659
ADH85295.1	ADH86885.1	DaAHT2_0589	DaAHT2_2220	PFAM: protein of unknown function DUF181; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; KEGG: dps:DP1955 hypothetical protein.	SMART: TRASH domain protein; KEGG: drt:Dret_1349 TRASH domain protein.	0.507
ADH85295.1	ADH87270.1	DaAHT2_0589	DaAHT2_2609	PFAM: protein of unknown function DUF181; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; KEGG: dps:DP1955 hypothetical protein.	KEGG: sat:SYN_02055 rRNA methylase; TIGRFAM: RNA methyltransferase, TrmH family, group 1; PFAM: tRNA/rRNA methyltransferase (SpoU).	0.414
ADH85444.1	ADH86074.1	DaAHT2_0740	DaAHT2_1379	SMART: ParB domain protein nuclease; KEGG: sfu:Sfum_1262 hypothetical protein.	PFAM: UspA domain protein; KEGG: dol:Dole_1866 UspA domain-containing protein.	0.558
ADH86074.1	ADH85262.1	DaAHT2_1379	DaAHT2_0556	PFAM: UspA domain protein; KEGG: dol:Dole_1866 UspA domain-containing protein.	KEGG: dps:DP2176 hypothetical protein.	0.663
ADH86074.1	ADH85295.1	DaAHT2_1379	DaAHT2_0589	PFAM: UspA domain protein; KEGG: dol:Dole_1866 UspA domain-containing protein.	PFAM: protein of unknown function DUF181; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; KEGG: dps:DP1955 hypothetical protein.	0.737
ADH86074.1	ADH85444.1	DaAHT2_1379	DaAHT2_0740	PFAM: UspA domain protein; KEGG: dol:Dole_1866 UspA domain-containing protein.	SMART: ParB domain protein nuclease; KEGG: sfu:Sfum_1262 hypothetical protein.	0.558
ADH86074.1	ADH86612.1	DaAHT2_1379	DaAHT2_1932	PFAM: UspA domain protein; KEGG: dol:Dole_1866 UspA domain-containing protein.	KEGG: dps:DP2929 hypothetical protein.	0.599
ADH86074.1	ADH86642.1	DaAHT2_1379	DaAHT2_1964	PFAM: UspA domain protein; KEGG: dol:Dole_1866 UspA domain-containing protein.	KEGG: dps:DP0127 hypothetical protein.	0.680

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.826

expected number of edges:

14

PPI enrichment p-value:

0.000947

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032377

Regulation of intracellular lipid transport

3 of 3

3.04

2.42

4.06e-05

GO:0032370

Positive regulation of lipid transport

3 of 4

2.92

2.41

4.06e-05

GO:0008206

Bile acid metabolic process

3 of 6

2.74

2.39

4.06e-05

GO:0032388

Positive regulation of intracellular transport

3 of 12

2.44

2.15

9.19e-05

GO:0006635

Fatty acid beta-oxidation

4 of 57

1.89

1.96

7.59e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019107

Myristoyltransferase activity

3 of 4

2.92

2.47

3.15e-05

GO:0008525

Phosphatidylcholine transporter activity

3 of 4

2.92

2.47

3.15e-05

GO:0120015

Sterol transfer activity

3 of 12

2.44

2.06

0.00014

GO:0003988

acetyl-CoA C-acyltransferase activity

3 of 12

2.44

2.06

0.00014

GO:0120014

Phospholipid transfer activity

3 of 13

2.4

2.05

0.00014

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005777

Peroxisome

5 of 131

1.62

1.77

6.23e-05

GO:0005782

Peroxisomal matrix

3 of 25

2.12

1.69

0.00052

GO:0005739

Mitochondrion

7 of 1098

0.85

0.66

0.0021

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11194

Mixed, incl. Regulation of intracellular lipid transport, and Protein import into peroxisome matrix

5 of 12

2.66

4.92

3.93e-10

CL:11090

Fatty acid beta-oxidation, and Acyl-CoA dehydrogenase, N-terminal domain

7 of 71

2.03

4.16

2.37e-10

CL:11197

Protein import into peroxisome matrix, and Regulation of intracellular lipid transport

3 of 7

2.67

2.79

6.65e-06

CL:11166

Electron transfer flavoprotein domain, and Medium-chain fatty acid catabolic process

2 of 5

2.64

1.54

0.0015

CL:17674

Carbonic anhydrase, and Enoyl-CoA hydratase/isomerase

2 of 10

2.34

1.27

0.0045

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00910

Nitrogen metabolism

4 of 65

1.83

2.07

3.03e-05

map04146

Peroxisome

5 of 161

1.53

1.76

3.03e-05

map01040

Biosynthesis of unsaturated fatty acids

3 of 118

1.45

0.95

0.0077

map01212

Fatty acid metabolism

3 of 204

1.21

0.66

0.0281

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-390918

Peroxisomal lipid metabolism

5 of 81

1.83

2.31

6.73e-06

MAP-2046106

Alpha-linolenic acid (ALA) metabolism

3 of 26

2.1

1.57

0.00094

MAP-2046104

Alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

3 of 26

2.1

1.57

0.00094

MAP-389887

Beta-oxidation of pristanoyl-CoA

3 of 34

1.99

1.53

0.00094

MAP-193368

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

3 of 60

1.74

1.26

0.0025

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0012

Acyltransferase

3 of 34

1.99

1.52

0.0010

KW-0456

Lyase

3 of 74

1.65

1.11

0.0048

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02803

Thiolase, C-terminal domain

3 of 10

2.52

2.03

0.00017

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020617

Thiolase, C-terminal

3 of 10

2.52

1.86

0.00036

IPR020616

Thiolase, N-terminal

3 of 10

2.52

1.86

0.00036

IPR020613

Thiolase, conserved site

3 of 9

2.56

1.86

0.00036

IPR016039

Thiolase-like

3 of 20

2.22

1.65

0.00072

IPR014730

Electron transfer flavoprotein, alpha/beta-subunit, N-terminal

2 of 2

3.04

1.43

0.0026

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00893

Electron transfer flavoprotein domain

2 of 2

3.04

1.58

0.0014

SM00947

Carbonic anhydrase

2 of 7

2.5

1.29

0.0043

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About