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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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ADH86682.1KEGG: gur:Gura_1891 hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase. (229 aa)    
Predicted Functional Partners:
ADH85844.1
PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: gwc:GWCH70_0053 MazG family protein.
  
  
  0.919
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
    
 0.917
surE
Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.911
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.907
ADH85349.1
Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
   
 
 0.906
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
     
  0.903
ADH86115.1
PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: dps:DP1741 bifunctional phospho ribosylaminoimidazole carboxamide formyltransferase/IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme formylation region.
    
  0.901
ADH86759.1
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
     
  0.900
ADH86968.1
PFAM: protein of unknown function DUF152; KEGG: dal:Dalk_1940 protein of unknown function DUF152; Belongs to the multicopper oxidase YfiH/RL5 family.
    
  0.900
ADH87224.1
TIGRFAM: hypoxanthine phosphoribosyltransferase; KEGG: hmo:HM1_0058 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
  0.900
Your Current Organism:
Desulfurivibrio alkaliphilus
NCBI taxonomy Id: 589865
Other names: D. alkaliphilus AHT 2, Desulfurivibrio alkaliphilus AHT 2, Desulfurivibrio alkaliphilus str. AHT 2, Desulfurivibrio alkaliphilus strain AHT 2
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