STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ferp_2162TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; KEGG: afu:AF1719 acetolactate synthase 3 regulatory subunit. (161 aa)    
Predicted Functional Partners:
Ferp_2163
TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; KEGG: afu:AF1720 acetolactate synthase 3 catalytic subunit.
 
 0.999
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.989
Ferp_2126
KEGG: afu:AF0628 multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase.
  
 0.987
cimA
Isopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.969
Ferp_2288
TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: afu:AF0219 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.939
Ferp_0894
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein; KEGG: afu:AF1701 pyruvate ferredoxin oxidoreductase, subunit alpha (PorA).
  
 
 0.917
Ferp_1299
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; KEGG: afu:AF0749 2-oxoacid ferredoxin oxidoreductase, subunit alpha (orA).
  
 
 0.917
Ferp_1824
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: afu:AF2053 2-ketoisovalerate ferredoxin oxidoreductase, subunit alpha (VorA).
  
 
 0.917
Ferp_0892
TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: afu:AF1699 pyruvate ferredoxin oxidoreductase subunit gamma.
    
 0.907
Ferp_0895
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: afu:AF1702 pyruvate ferredoxin oxidoreductase, subunit beta (PorB).
    
 0.907
Your Current Organism:
Ferroglobus placidus
NCBI taxonomy Id: 589924
Other names: F. placidus DSM 10642, Ferroglobus placidus AEDII12DO, Ferroglobus placidus DSM 10642, Ferroglobus placidus str. DSM 10642, Ferroglobus placidus strain DSM 10642
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