STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
G3B770_CANTCHistone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (338 aa)    
Predicted Functional Partners:
G3BF36_CANTC
Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
   
 0.980
G3BBE8_CANTC
SET domain-containing protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
   
 0.978
G3B4D3_CANTC
Histone H3; Belongs to the histone H3 family.
   
 0.942
G3B4D2_CANTC
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 
 0.936
G3AWY4_CANTC
SET domain-containing protein.
   
 0.929
G3AXG7_CANTC
Uncharacterized protein.
     
  0.900
G3B0Y9_CANTC
Ubiquitin.
   
   0.882
G3AX77_CANTC
Ubiquitin-like domain-containing protein.
   
   0.880
G3B104_CANTC
Histone H3; Belongs to the histone H3 family.
   
 0.839
G3B3N8_CANTC
Histone-fold-containing protein.
   
 0.839
Your Current Organism:
Yamadazyma tenuis
NCBI taxonomy Id: 590646
Other names: Candida tenuis ATCC 10573, Y. tenuis ATCC 10573, Yamadazyma tenuis ATCC 10573
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