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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (272 aa)    
Predicted Functional Partners:
fhs
PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: ctc:CTC02304 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
 
 0.996
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 0.972
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 
 0.960
ADB48206.1
PFAM: methylenetetrahydrofolate reductase; KEGG: ank:AnaeK_2769 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
 
  
 0.948
ADB47702.1
IMP cyclohydrolase; KEGG: bfr:BF2666 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; PFAM: AICARFT/IMPCHase bienzyme formylation region; SMART: AICARFT/IMPCHase bienzyme formylation region.
  
 
 0.945
ADB46645.1
PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase.
    
 0.942
ADB47881.1
TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: cno:NT01CX_1657 5-formyltetrahydrofolate cyclo-ligase family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
  
 
 0.922
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.907
ADB46643.1
KEGG: ctc:CTC02305 glutamate formiminotransferase; TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase domain protein.
    
  0.904
nusB
NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
  
  
 0.847
Your Current Organism:
Acidaminococcus fermentans
NCBI taxonomy Id: 591001
Other names: A. fermentans DSM 20731, Acidaminococcus fermentans DSM 20731, Acidaminococcus fermentans str. DSM 20731, Acidaminococcus fermentans strain DSM 20731
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