Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADB46709.1TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: mta:Moth_1248 uroporphyrinogen-III C- methyltransferase / uroporphyrinogen-III synthase; Belongs to the precorrin methyltransferase family. (489 aa)    
Predicted Functional Partners:
ADB46708.1
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
 0.999
ADB46710.1
TIGRFAM: siroheme synthase; KEGG: ttu:TERTU_1974 siroheme synthase.
 
 0.999
ADB48093.1
PFAM: nitrite and sulphite reductase 4Fe-4S region; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; KEGG: cpr:CPR_0512 nitrite/sulfite reductase-like protein.
 
  
 0.898
ADB46707.1
PFAM: BioY protein; KEGG: dae:Dtox_4332 BioY protein.
       0.784
ADB47446.1
KEGG: ckr:CKR_3419 hypothetical protein.
  
  
 0.769
ADB46759.1
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.690
ADB47169.1
PFAM: nitroreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: cbe:Cbei_3948 nitroreductase.
  
  
 0.627
ADB48204.1
PFAM: homocysteine S-methyltransferase; dihydropteroate synthase DHPS; Methionine synthase B12- binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: aoe:Clos_0080 homocysteine S- methyltransferase.
 
  
 0.607
ADB47552.1
PFAM: amine oxidase; KEGG: bad:BAD_1455 hypothetical protein.
  
  
 0.586
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
  
 0.578
Your Current Organism:
Acidaminococcus fermentans
NCBI taxonomy Id: 591001
Other names: A. fermentans DSM 20731, Acidaminococcus fermentans DSM 20731, Acidaminococcus fermentans str. DSM 20731, Acidaminococcus fermentans strain DSM 20731
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