Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
hgdHD-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; Catalyzes the reduction of 2-oxoglutarate to 2- hydroxyglutarate. (331 aa)    
Predicted Functional Partners:
ADB46956.1
TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PEP-utilising protein mobile region; KEGG: bbe:BBR47_13840 pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.742
ADB46892.1
TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin iron-sulfur binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; KEGG: cby:CLM_3126 pyruvate ferredoxin oxidoreductase.
  
  
 0.661
ADB47350.1
PFAM: protein of unknown function DUF344; KEGG: cyt:cce_2971 putative polyphosphate kinase 2.
  
    0.541
ADB47345.1
KEGG: rpt:Rpal_5127 alpha/beta hydrolase fold.
     
 0.519
ADB47346.1
PFAM: thioesterase superfamily protein; KEGG: pth:PTH_2715 hypothetical protein.
  
    0.478
rnr
Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
       0.476
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
       0.476
ADB47932.1
PFAM: acyl-CoA dehydrogenase domain protein; Electron transfer flavoprotein alpha subunit; Rubredoxin- type Fe(Cys)4 protein; KEGG: cbi:CLJ_B3073 acyl-CoA dehydrogenase family protein/electron transfer protein.
  
 
 0.465
ADB47055.1
Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: glo:Glov_0565 multi-sensor hybrid histidine kinase.
 
  
 0.460
ADB47196.1
PFAM: peptidase U34 dipeptidase; KEGG: bad:BAD_0168 dipeptidase.
   
    0.460
Your Current Organism:
Acidaminococcus fermentans
NCBI taxonomy Id: 591001
Other names: A. fermentans DSM 20731, Acidaminococcus fermentans DSM 20731, Acidaminococcus fermentans str. DSM 20731, Acidaminococcus fermentans strain DSM 20731
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