Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADB47373.1PFAM: PP-loop domain protein; KEGG: ckr:CKR_2212 hypothetical protein. (275 aa)    
Predicted Functional Partners:
ADB47374.1
PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; KEGG: amt:Amet_0480 1-(5-phosphoribosyl)-5-amino-4- imidazole-carboxylate (AIR) carboxylase.
 
 
 0.992
larC
Protein of unknown function DUF111; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family.
 
 0.990
ADB47376.1
PFAM: cobalamin (vitamin B12) biosynthesis CbiM protein; KEGG: cpy:Cphy_0681 cobalamin (vitamin B12) biosynthesis CbiM protein.
 
    0.909
ADB47377.1
PFAM: cobalt transport protein; KEGG: hmo:HM1_3001 cobalt abc transporter, permease protein CbiQ.
 
    0.902
ADB47697.1
PFAM: PP-loop domain protein; SMART: Rhodanese domain protein; KEGG: ere:EUBREC_1362 putative ATPase of the PP- loop superfamily implicated in cell cycle control; Belongs to the TtcA family.
 
    0.725
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
    0.717
ADB47378.1
PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: cce:Ccel_1184 cobalt ABC transporter, ATPase subunit.
  
    0.651
ADB47372.1
Hypothetical protein.
       0.470
Your Current Organism:
Acidaminococcus fermentans
NCBI taxonomy Id: 591001
Other names: A. fermentans DSM 20731, Acidaminococcus fermentans DSM 20731, Acidaminococcus fermentans str. DSM 20731, Acidaminococcus fermentans strain DSM 20731
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