node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADB47083.1 | murI | Acfer_0691 | Acfer_0031 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.907 |
ADB47083.1 | murI-2 | Acfer_0691 | Acfer_1754 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.776 |
ADB47331.1 | glsA | Acfer_0950 | Acfer_0049 | PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: cdf:CD2842 nitrilase (carbon-nitrogen hydrolase). | PFAM: Glutaminase, core; KEGG: cpr:CPR_1963 glutaminase; Belongs to the glutaminase family. | 0.811 |
ADB47331.1 | murI | Acfer_0950 | Acfer_0031 | PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: cdf:CD2842 nitrilase (carbon-nitrogen hydrolase). | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.802 |
ADB47331.1 | murI-2 | Acfer_0950 | Acfer_1754 | PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: cdf:CD2842 nitrilase (carbon-nitrogen hydrolase). | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.802 |
ADB48109.1 | murI-2 | Acfer_1753 | Acfer_1754 | PFAM: Helix-turn-helix type 11 domain protein; 3H domain protein; KEGG: esi:Exig_2103 3H domain-containing protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.487 |
glsA | ADB47331.1 | Acfer_0049 | Acfer_0950 | PFAM: Glutaminase, core; KEGG: cpr:CPR_1963 glutaminase; Belongs to the glutaminase family. | PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: cdf:CD2842 nitrilase (carbon-nitrogen hydrolase). | 0.811 |
glsA | murD | Acfer_0049 | Acfer_1303 | PFAM: Glutaminase, core; KEGG: cpr:CPR_1963 glutaminase; Belongs to the glutaminase family. | UDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.900 |
glsA | murI | Acfer_0049 | Acfer_0031 | PFAM: Glutaminase, core; KEGG: cpr:CPR_1963 glutaminase; Belongs to the glutaminase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.911 |
glsA | murI-2 | Acfer_0049 | Acfer_1754 | PFAM: Glutaminase, core; KEGG: cpr:CPR_1963 glutaminase; Belongs to the glutaminase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.911 |
mraY | murC | Acfer_1304 | Acfer_1301 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.920 |
mraY | murD | Acfer_1304 | Acfer_1303 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.963 |
mraY | murF | Acfer_1304 | Acfer_1305 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate/ D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.997 |
mraY | murG | Acfer_1304 | Acfer_1302 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.990 |
mraY | murI | Acfer_1304 | Acfer_0031 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.458 |
mraY | murI-2 | Acfer_1304 | Acfer_1754 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.452 |
murC | mraY | Acfer_1301 | Acfer_1304 | UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.920 |
murC | murD | Acfer_1301 | Acfer_1303 | UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | UDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.995 |
murC | murF | Acfer_1301 | Acfer_1305 | UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate/ D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.828 |
murC | murG | Acfer_1301 | Acfer_1302 | UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.986 |