STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pus10THUMP domain protein; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. (437 aa)    
Predicted Functional Partners:
srp54
GTP-binding signal recognition particle SRP54 G- domain protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
       0.870
ADI31176.1
Hypothetical protein.
       0.828
rpl21e
PFAM: Ribosomal protein L21e; KEGG: hypothetical protein; K02889 large subunit ribosomal protein L21e; Belongs to the eukaryotic ribosomal protein eL21 family.
 
   
 0.758
ADI31302.1
KEGG: similar to Methyltransferase-like protein 5.
 
   
 0.646
ADI32301.1
KEGG: MGC98839; N2,N2-dimethylguanosine tRNA methyltransferase-like; PFAM: N2N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
  
   
 0.630
ADI31171.1
KEGG: rty:RT0666 dimethyladenosine transferase; PFAM: ribosomal RNA adenine methylase transferase; SMART: Ribosomal RNA adenine methylase transferase-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
 
   
 0.619
ADI31173.1
RNA polymerase Rpb4; KEGG: MGC85403 protein; K03012 DNA-directed RNA polymerase II subunit D; PFAM: RNA polymerase Rpb4; SMART: RNA polymerase II, Rpb4, core.
     
 0.576
priL
DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
  
     0.529
ADI31218.1
PFAM: protein of unknown function Met10; KEGG: similar to tRNA-(N1G37) methyltransferase.
  
  
 0.525
ADI31227.1
PFAM: tRNA pseudouridine synthase D TruD; KEGG: gur:Gura_0971 tRNA pseudouridine synthase D, TruD.
  
  
 0.518
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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