Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
fau-1Protein of unknown function DUF402; Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences. (476 aa)    
Predicted Functional Partners:
ADI31311.1
PFAM: Protein of unknown function UPF0147; Belongs to the UPF0147 family.
       0.823
flpA
Fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
 
 
 0.632
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
   
 
 0.590
ADI32181.1
PFAM: PhoH family protein; KH type 2 domain protein; KEGG: aap:NT05HA_0191 PhoH.
 
    0.556
ADI31590.1
PFAM: extracellular solute-binding protein family 5; KEGG: kpu:KP1_5245 periplasmic dipeptide transport protein precursor.
  
   
 0.519
ADI32213.1
Hypothetical protein; KEGG: pat:Patl_0427 hydroxymethylglutaryl-CoA reductase (NADPH).
  
     0.517
ADI31312.1
PFAM: Sjogrens syndrome scleroderma autoantigen 1.
       0.499
ADI32400.1
Aminopeptidase Iap family-like protein; KEGG: rbo:A1I_03535 TPR repeat-containing protein kinase.
  
     0.491
ADI31831.1
PFAM: extracellular solute-binding protein family 1; KEGG: dze:Dd1591_4126 extracellular solute-binding protein family 1.
  
     0.464
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
 
  
 0.424
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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