Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tmkTIGRFAM: thymidylate kinase; KEGG: scl:sce0834 putative thymidylate kinase; PFAM: thymidylate kinase. (199 aa)    
Predicted Functional Partners:
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.922
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
    
 0.922
ADI31206.1
Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
  
 
  0.908
ADI31314.1
KEGG: noc:Noc_2211 transposase IS605; TIGRFAM: transposase, IS605 OrfB family; PFAM: transposase IS605 OrfB.
       0.773
ADI31315.1
PFAM: protein of unknown function DUF126; KEGG: sme:SM_b20269 hypothetical protein.
       0.757
ADI31316.1
PFAM: protein of unknown function DUF521; KEGG: bam:Bamb_5490 hypothetical protein.
       0.755
ADI31317.1
KEGG: bpy:Bphyt_2187 UbiD family decarboxylase; TIGRFAM: UbiD family decarboxylase; PFAM: Carboxylyase-related protein.
       0.721
ADI31318.1
GTPase or GTP-binding protein-like protein; KEGG: AAA family ATPase Grc3 (predicted); K06947.
       0.721
ADI31319.1
Hypothetical protein.
       0.690
carS
Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.
     
 0.584
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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