STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADI31587.1Protein of unknown function DUF650; Involved in DNA damage repair; Belongs to the Nre family. (422 aa)    
Predicted Functional Partners:
ADI31588.1
PFAM: Radical SAM domain protein; KEGG: tau:Tola_1404 radical SAM domain protein.
       0.864
priS
DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]
 
     0.625
nac
alpha-NAC related protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
  
     0.571
ADI32333.1
Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication.
  
     0.562
ADI32363.1
PFAM: protein of unknown function DUF120; KEGG: geo:Geob_0130 HAD-superfamily hydrolase, subfamily IA, variant 3.
  
     0.552
dnaG
TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
  
     0.547
ADI32631.1
Phosphate uptake regulator, PhoU; PFAM: PhoU family protein; SpoVT/AbrB domain protein; KEGG: bba:Bd2221 Na/Pi-cotransporter family protein.
  
     0.527
ADI31391.1
KEGG: glo:Glov_0622 phosphate uptake regulator, PhoU; TIGRFAM: transcriptional regulator, AbrB family; PFAM: PhoU family protein; SpoVT/AbrB domain protein.
  
     0.498
rpl18e
PFAM: ribosomal protein L15; KEGG: hypothetical protein; Belongs to the eukaryotic ribosomal protein eL18 family.
  
     0.498
ADI31586.1
Hypothetical protein; KEGG: vha:VIBHAR_05158 transcriptional regulatory protein CpxR.
       0.489
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.