Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADI31674.1DNA polymerase B region; KEGG: hypothetical protein; K02320 DNA polymerase alpha subunit A; PFAM: DNA polymerase B region; SMART: DNA-directed DNA polymerase B. (648 aa)    
Predicted Functional Partners:
ADI32668.1
SMART: DNA-directed DNA polymerase B; TIGRFAM: DNA polymerase Pol2; KEGG: pold1; polymerase (DNA directed), delta 1, catalytic subunit 125kDa; K02327 DNA polymerase delta subunit 1; PFAM: DNA polymerase B region; DNA polymerase B exonuclease.
  
  
 
0.927
ADI32684.1
PFAM: DNA polymerase B region; DNA polymerase B exonuclease; KEGG: hypothetical protein; K02320 DNA polymerase alpha subunit A; SMART: DNA-directed DNA polymerase B.
  
  
 
0.922
ADI32328.1
MCM family protein; KEGG: hypothetical protein; K02540 minichromosome maintenance protein 2; PFAM: MCM family protein; SMART: MCM family protein; Hedgehog/intein hint domain protein; Belongs to the MCM family.
  
 0.895
priL
DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
   
 0.892
priS
DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]
   
 0.873
ADI31672.1
Hypothetical protein.
       0.854
ADI31673.1
Hypothetical protein.
     
 0.839
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 0.791
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
   
 0.784
pcn
Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
 0.783
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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