Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADI31769.1KEGG: ppf:Pput_3073 hydroxymethylglutaryl-CoA reductase, degradative; TIGRFAM: hydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family. (428 aa)    
Predicted Functional Partners:
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 0.995
ADI32215.1
hydroxymethylglutaryl-CoA synthase; KEGG: pfl:PFL_5954 hypothetical protein; TIGRFAM: hydroxymethylglutaryl-CoA synthase; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; Belongs to the thiolase-like superfamily. UPF0219 family.
  
 
 0.986
ADI32213.1
Hypothetical protein; KEGG: pat:Patl_0427 hydroxymethylglutaryl-CoA reductase (NADPH).
     
  0.900
fni
Isopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
    
 0.795
ADI31441.1
PFAM: Polyprenyl synthetase; KEGG: scl:sce4204 geranyltranstransferase; Belongs to the FPP/GGPP synthase family.
  
 
 0.614
ADI31770.1
Hypothetical protein.
       0.451
ADI31360.1
KEGG: wpi:WPa_0101 orotidine 5`-phosphate decarboxylase; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase.
     
 0.403
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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