Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADI31813.1PFAM: amidohydrolase; KEGG: D-hydantoinase; K01465 dihydroorotase. (447 aa)    
Predicted Functional Partners:
pyrB
KEGG: aspartate carabmoyltransferase, chloroplast / aspartate transcarbamylase / ATCase (PYRB); K00609 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region.
 
 0.988
ADI31705.1
KEGG: dihydroorotate dehydrogenase family protein; TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate oxidase; 4Fe-4S ferredoxin iron-sulfur binding domain protein.
 
 
 0.898
arcB
TIGRFAM: ornithine carbamoyltransferase; KEGG: sat:SYN_02156 ornithine carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region.
 
  
 0.885
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
  
 0.859
ADI31360.1
KEGG: wpi:WPa_0101 orotidine 5`-phosphate decarboxylase; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase.
  
  
 0.832
ADI31356.1
PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: sat:SYN_02220 oxidoreductase.
 
  
 0.822
pyrD
Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate.
 
 
 0.817
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.684
ADI31661.1
PFAM: multiple antibiotic resistance (MarC)-related protein; KEGG: sat:SYN_01458 MarC family integral membrane protein.
       0.419
cysS
KEGG: sfu:Sfum_1634 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; tRNA synthetase class I (M); Cysteinyl-tRNA synthetase class Ia DALR.
  
  
 0.416
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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