STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADI31946.1SMART: Elongator protein 3/MiaB/NifB; TIGRFAM: histone acetyltransferase, ELP3 family; KEGG: AGAP008300-PA; K07739 elongator complex protein 3; PFAM: Radical SAM domain protein; GCN5-related N-acetyltransferase. (498 aa)    
Predicted Functional Partners:
ADI32032.1
PFAM: Methyltransferase type 12; Methyltransferase type 11; KEGG: hypothetical protein.
 
 
 0.643
rtcA
RNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
   
  
 0.600
ADI31532.1
PFAM: NMD3 family protein.
   
  
 0.567
ADI32453.1
PFAM: NMD3 family protein.
   
  
 0.567
ADI31945.1
PFAM: beta-lactamase domain protein; Belongs to the UPF0282 family.
       0.554
dphB
Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
  
  
 0.538
tuf
Translation elongation factor EF-1, subunit alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
    
 
 0.520
ADI31171.1
KEGG: rty:RT0666 dimethyladenosine transferase; PFAM: ribosomal RNA adenine methylase transferase; SMART: Ribosomal RNA adenine methylase transferase-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
   
  
 0.496
ADI31395.1
KEGG: sfu:Sfum_2757 SUA5/YciO/YrdC/YwlC family protein; TIGRFAM: Sua5/YciO/YrdC/YwlC family protein; PFAM: SUA5/yciO/yrdC domain.
 
   0.492
ADI32301.1
KEGG: MGC98839; N2,N2-dimethylguanosine tRNA methyltransferase-like; PFAM: N2N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
  
  
 0.474
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.