Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
speESpermine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family. (286 aa)    
Predicted Functional Partners:
speH
S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
 
 
 0.994
ADI32424.1
Agmatinase; KEGG: pub:SAR11_1329 agmatinase; TIGRFAM: agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; Belongs to the arginase family.
  
 
 0.972
mtnP
Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
  
 
 0.939
ADI31728.1
S-adenosylhomocysteine deaminase; KEGG: dal:Dalk_5014 amidohydrolase; PFAM: amidohydrolase.
   
 0.912
ADI31417.1
PFAM: purine or other phosphorylase family 1; KEGG: aha:AHA_3168 uridine phosphorylase.
     
  0.900
ADI32116.1
KEGG: gem:GM21_2025 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase.
       0.724
nac
alpha-NAC related protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
   
   0.568
ADI32118.1
PFAM: ATP dependent DNA ligase; KEGG: noc:Noc_1413 ATP-dependent DNA ligase.
       0.553
ADI32115.1
KEGG: hypothetical protein.
       0.535
ADI32119.1
Hypothetical protein.
       0.522
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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