STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADI32177.1DNA-(apurinic or apyrimidinic site) lyase; PFAM: HhH-GPD family protein; iron-sulfur cluster loop; KEGG: rcm:A1E_04790 endonuclease III; SMART: HhH-GPD family protein; iron-sulfur cluster loop. (234 aa)    
Predicted Functional Partners:
ADI32176.1
KEGG: afw:Anae109_2720 asparaginyl-tRNA synthetase; TIGRFAM: asparaginyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type.
  
  
 0.840
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 
 0.648
ADI31485.1
PFAM: Xylose isomerase domain protein TIM barrel.
  
 
 0.645
ADI32378.1
Hypothetical protein.
  
 
 0.645
ADI31705.1
KEGG: dihydroorotate dehydrogenase family protein; TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate oxidase; 4Fe-4S ferredoxin iron-sulfur binding domain protein.
  
  
 0.483
ADI32269.1
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
 
  
 0.463
ADI32175.1
KEGG: ARD1B; ARD1 homolog B (S. cerevisiae); TIGRFAM: ribosomal-protein-alanine acetyltransferase; PFAM: GCN5-related N-acetyltransferase.
       0.460
ADI31767.1
PFAM: ERCC4 domain protein; helix-hairpin-helix motif; KEGG: sbn:Sbal195_0376 ERCC4 domain-containing protein.
    
 
 0.443
ADI31902.1
PFAM: Beta propeller domain; KEGG: hypothetical protein.
    
 
 0.443
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
     
 0.442
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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