Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADI32215.1hydroxymethylglutaryl-CoA synthase; KEGG: pfl:PFL_5954 hypothetical protein; TIGRFAM: hydroxymethylglutaryl-CoA synthase; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; Belongs to the thiolase-like superfamily. UPF0219 family. (352 aa)    
Predicted Functional Partners:
ADI32129.1
PFAM: Thiolase; KEGG: gur:Gura_4354 thiolase.
 
 0.999
ADI32214.1
PFAM: protein of unknown function DUF35; KEGG: rme:Rmet_5539 hypothetical protein.
 
 
 0.998
ADI32213.1
Hypothetical protein; KEGG: pat:Patl_0427 hydroxymethylglutaryl-CoA reductase (NADPH).
 
 
 0.997
ADI31769.1
KEGG: ppf:Pput_3073 hydroxymethylglutaryl-CoA reductase, degradative; TIGRFAM: hydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family.
  
 
 0.986
ADI32104.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: ppd:Ppro_0325 thiamine pyrophosphate binding domain-containing protein.
     
 0.901
ADI32107.1
KEGG: sfu:Sfum_2792 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase.
    
  0.901
ADI32111.1
KEGG: dat:HRM2_41100 PorB3; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate protein domain protein TPP-binding.
     
 0.901
ADI32549.1
TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; KEGG: sfu:Sfum_0543 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase.
    
  0.901
ADI32552.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: dol:Dole_1391 thiamine pyrophosphate binding domain-containing protein.
     
 0.901
ADI32105.1
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: ppd:Ppro_0324 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein.
     
  0.900
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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