Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (275 aa)    
Predicted Functional Partners:
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
    
 0.935
ADI32061.1
TIGRFAM: cytidyltransferase-related domain protein; KEGG: dac:Daci_5608 cytidyltransferase-like protein; PFAM: cytidylyltransferase.
 
  
 0.934
ADI32617.1
TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-related domain protein; KEGG: hch:HCH_06993 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; PFAM: cytidylyltransferase.
 
  
 0.933
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.813
ADI31479.1
PFAM: Quinolinate phosphoribosyl transferase; KEGG: ilo:IL0103 nicotinate phosphoribosyltransferase.
 
  
 0.640
ADI32241.1
PFAM: AMMECR1 domain protein; KEGG: dal:Dalk_3956 AMMECR1 domain protein.
       0.607
ADI32242.1
PFAM: protein of unknown function DUF82; KEGG: rme:Rmet_0174 hypothetical protein.
       0.607
ADI32243.1
CBS domain containing protein; KEGG: pca:Pcar_0067 putative inosine monophosphate dehydrogenase; PFAM: CBS domain containing protein; SMART: CBS domain containing protein.
  
    0.478
ADI32244.1
Putative signal transduction protein with CBS domains; KEGG: dma:DMR_17080 hypothetical protein; PFAM: CBS domain containing protein; SMART: CBS domain containing protein.
  
    0.466
ADI32059.1
KEGG: dat:HRM2_26920 BirA; TIGRFAM: biotin/acetyl-CoA-carboxylase ligase; PFAM: biotin/lipoate A/B protein ligase.
 
  
 0.464
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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