Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADI32317.1PFAM: putative RNA methylase; DNA methylase N-4/N-6 domain protein; KEGG: similar to tRNA guanosine-2-O-methyltransferase TRM11 homolog. (337 aa)    
Predicted Functional Partners:
rnz
Beta-lactamase domain protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
  
    0.913
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
  
   0.852
rtcA
RNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
  
    0.717
ADI31170.1
PFAM: methyltransferase small; KEGG: msu:MS1588 16S ribosomal RNA m2G1207 methyltransferase.
    
 
 0.703
ADI32301.1
KEGG: MGC98839; N2,N2-dimethylguanosine tRNA methyltransferase-like; PFAM: N2N2-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
  
 
 0.669
ADI31299.1
PFAM: RNA polymerase dimerisation; KEGG: similar to DNA-directed RNA polymerase II 13.3 kDa polypeptide (RPB11); K03008 DNA-directed RNA polymerase II subunit J.
 
    0.636
ADI31216.1
SMART: Nucleotide binding protein PINc; KEGG: predicted protein; K11883 RNA-binding protein NOB1.
  
    0.616
ADI32311.1
KEGG: viral A-type inclusion protein.
 
     0.589
ADI32314.1
PFAM: protein of unknown function ATP binding; KEGG: ATP-binding protein; K06883.
       0.584
ADI32694.1
Brix domain protein; Probably involved in the biogenesis of the ribosome.
  
    0.576
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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