Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADI32456.1TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: Radical SAM domain protein; Protein of unknown function UPF0004; KEGG: SORBIDRAFT_06g017040; hypothetical protein; SMART: Elongator protein 3/MiaB/NifB. (429 aa)    
Predicted Functional Partners:
eif2b
Translation initiation factor IF2/IF5; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family.
       0.730
rrp41
Exosome complex exonuclease 1; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
 
   0.691
rrp4
K-like, type 1, subgroup; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
   
 
 0.689
eif1a
S1 IF1 family protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
  
  
 0.605
ADI32454.1
PFAM: Protein of unknown function DUF424.
       0.604
ADI32451.1
RIO-like kinase; KEGG: RIO1 family protein; K07178 RIO kinase 1; PFAM: RIO-like kinase; SMART: protein of unknown function RIO1.
       0.581
ADI32450.1
TIGRFAM: KH domain protein; PFAM: K Homology, type 1, subgroup; KEGG: similar to RNA-binding protein PNO1; K11884 RNA-binding protein PNO1; SMART: KH domain protein.
       0.572
ADI32453.1
PFAM: NMD3 family protein.
  
    0.526
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
  
  
 0.515
ADI31490.1
PFAM: Thiamine biosynthesis protein-like; Queuosine synthesis-like; KEGG: bpn:BPEN_246 thiamine biosynthesis protein ThiI.
  
  
 0.515
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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