| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADI32699.1 | pfdB | Shell_1612 | Shell_1605 | PFAM: Ribosome maturation protein SBDS-like; KEGG: hypothetical protein, conserved. | Prefoldin, beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 0.851 |
| ADI32699.1 | psmA | Shell_1612 | Shell_1613 | PFAM: Ribosome maturation protein SBDS-like; KEGG: hypothetical protein, conserved. | Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.863 |
| ADI32699.1 | rpl37ae | Shell_1612 | Shell_1608 | PFAM: Ribosome maturation protein SBDS-like; KEGG: hypothetical protein, conserved. | Ribosomal L37ae protein; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily. | 0.985 |
| ADI32699.1 | rrp4 | Shell_1612 | Shell_1611 | PFAM: Ribosome maturation protein SBDS-like; KEGG: hypothetical protein, conserved. | K-like, type 1, subgroup; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. | 0.939 |
| ADI32699.1 | rrp41 | Shell_1612 | Shell_1610 | PFAM: Ribosome maturation protein SBDS-like; KEGG: hypothetical protein, conserved. | Exosome complex exonuclease 1; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails. | 0.924 |
| ADI32699.1 | rrp42 | Shell_1612 | Shell_1609 | PFAM: Ribosome maturation protein SBDS-like; KEGG: hypothetical protein, conserved. | 3' exoribonuclease; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. | 0.919 |
| glpK | pan | Shell_0551 | Shell_1551 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | 0.966 |
| glpK | pfdB | Shell_0551 | Shell_1605 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Prefoldin, beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 0.404 |
| glpK | psmA | Shell_0551 | Shell_1613 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.837 |
| glpK | psmB | Shell_0551 | Shell_1527 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.837 |
| glpK | psmB-2 | Shell_0551 | Shell_1533 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.837 |
| pan | glpK | Shell_1551 | Shell_0551 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | 0.966 |
| pan | psmA | Shell_1551 | Shell_1613 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.941 |
| pan | psmB | Shell_1551 | Shell_1527 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.876 |
| pan | psmB-2 | Shell_1551 | Shell_1533 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.876 |
| pfdB | ADI32699.1 | Shell_1605 | Shell_1612 | Prefoldin, beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | PFAM: Ribosome maturation protein SBDS-like; KEGG: hypothetical protein, conserved. | 0.851 |
| pfdB | glpK | Shell_1605 | Shell_0551 | Prefoldin, beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | 0.404 |
| pfdB | psmA | Shell_1605 | Shell_1613 | Prefoldin, beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.850 |
| pfdB | rpl37ae | Shell_1605 | Shell_1608 | Prefoldin, beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | Ribosomal L37ae protein; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily. | 0.921 |
| pfdB | rrp4 | Shell_1605 | Shell_1611 | Prefoldin, beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | K-like, type 1, subgroup; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. | 0.863 |
