Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EFL01271.1Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase. (488 aa)    
Predicted Functional Partners:
EFL01270.1
Branched-chain alpha keto acid dehydrogenase E1 beta subunit.
 0.999
EFL01269.1
Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit.
 
 0.996
EFL02609.1
Oxoglutarate dehydrogenase (succinyl-transferring), E1 component.
 
0.992
EFK99327.1
Dihydrolipoyl dehydrogenase.
 0.989
EFL00143.1
Dihydrolipoyl dehydrogenase.
 0.974
EFL03940.1
Dihydrolipoyl dehydrogenase.
 0.950
sucC
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.942
EFK99505.1
Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.934
EFK99330.1
Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.930
EFL03243.1
CoA-disulfide reductase.
 
 0.927
Your Current Organism:
Streptomyces sp. SPB78
NCBI taxonomy Id: 591157
Other names: S. sp. SPB78
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