STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
egtBSulfatase modifying factor; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. (445 aa)    
Predicted Functional Partners:
egtD
S-adenosyl-L-methionine-dependent methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family.
 
 0.999
egtC
Methyltransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.
 
 
 0.999
egtA
Glutamate-cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.
 
  
 0.999
EFL35924.1
Glutamine amidotransferase class-II.
 
 
 0.976
EFL30171.1
Secreted protein.
  
   0.884
EFL34982.1
Arylsulfatase.
  
   0.884
EFL37050.1
Rhamnosidase.
  
   0.884
EFL31320.1
Cysteine desulfurase, catalytic subunit CsdA; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
  
  
 0.839
EFL36447.1
Conserved hypothetical protein.
       0.780
pyrF
Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily.
     
 0.643
Your Current Organism:
Streptomyces viridochromogenes
NCBI taxonomy Id: 591159
Other names: S. viridochromogenes DSM 40736, Streptomyces viridochromogenes DSM 40736, Streptomyces viridochromogenes str. DSM 40736, Streptomyces viridochromogenes strain DSM 40736
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