Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
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textmining
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
Sfla_2011Two component transcriptional regulator, winged helix family; KEGG: sgr:SGR_2224 putative two-component system response regulator; PFAM: response regulator receiver; transcriptional regulator domain-containing protein; SMART: response regulator receiver; transcriptional regulator domain-containing protein. (245 aa)    
Predicted Functional Partners:
Sfla_2012
Integral membrane sensor signal transduction histidine kinase; KEGG: sgr:SGR_2225 putative two-component system sensor kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein.
 
   0.975
Sfla_1602
GAF sensor hybrid histidine kinase; KEGG: sgr:SGR_1773 putative two-component system sensor kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; histidine kinase HAMP region domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; histidine kinase HAMP region domain protein; response regulator receiver.
  
 
 0.916
Sfla_2836
Histidine kinase; KEGG: sgr:SGR_4008 putative two-component system sensor kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein.
 
 
 0.815
Sfla_3263
Integral membrane sensor signal transduction histidine kinase; KEGG: sgr:SGR_3794 putative two-component system sensor kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein.
 
 
 0.809
Sfla_1926
Integral membrane sensor signal transduction histidine kinase; KEGG: sgr:SGR_2134 putative two-component system sensor kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein.
 
 
 0.796
Sfla_1505
Integral membrane sensor signal transduction histidine kinase; KEGG: sgr:SGR_1669 putative two-component system sensor kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein.
 
 
 0.792
Sfla_5952
Integral membrane sensor signal transduction histidine kinase; KEGG: sma:SAV_4417 two-component system sensor kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein.
 
 
 0.789
Sfla_2351
Integral membrane sensor signal transduction histidine kinase; KEGG: sgr:SGR_2636 putative two-component system sensor kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein.
  
 
 0.781
Sfla_3062
Integral membrane sensor signal transduction histidine kinase; KEGG: sgr:SGR_3566 putative two-component system sensor kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein.
 
 
 0.755
Sfla_6257
Integral membrane sensor signal transduction histidine kinase; KEGG: scb:SCAB_10861 two component sensor kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein.
 
 
 0.753
Your Current Organism:
Streptomyces pratensis
NCBI taxonomy Id: 591167
Other names: S. pratensis ATCC 33331, Streptomyces flavogriseus ATCC 33331, Streptomyces pratensis ATCC 33331
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