node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDD37665.1 | SDD46875.1 | SAMN05421538_101489 | SAMN05421538_101671 | Glutamate synthase (NADPH/NADH) large chain. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.455 |
SDD37665.1 | SDE41549.1 | SAMN05421538_101489 | SAMN05421538_106175 | Glutamate synthase (NADPH/NADH) large chain. | GMP synthase-Glutamine amidotransferase. | 0.744 |
SDD37665.1 | guaA | SAMN05421538_101489 | SAMN05421538_10483 | Glutamate synthase (NADPH/NADH) large chain. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.930 |
SDD37665.1 | guaB | SAMN05421538_101489 | SAMN05421538_104228 | Glutamate synthase (NADPH/NADH) large chain. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.980 |
SDD37665.1 | purA | SAMN05421538_101489 | SAMN05421538_10272 | Glutamate synthase (NADPH/NADH) large chain. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.640 |
SDD37665.1 | purF | SAMN05421538_101489 | SAMN05421538_10198 | Glutamate synthase (NADPH/NADH) large chain. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.970 |
SDD37665.1 | purH | SAMN05421538_101489 | SAMN05421538_10343 | Glutamate synthase (NADPH/NADH) large chain. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.947 |
SDD46875.1 | SDD37665.1 | SAMN05421538_101671 | SAMN05421538_101489 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate synthase (NADPH/NADH) large chain. | 0.455 |
SDD46875.1 | SDD83216.1 | SAMN05421538_101671 | SAMN05421538_102537 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.918 |
SDD46875.1 | SDE41549.1 | SAMN05421538_101671 | SAMN05421538_106175 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase-Glutamine amidotransferase. | 0.757 |
SDD46875.1 | gpt | SAMN05421538_101671 | SAMN05421538_102471 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.918 |
SDD46875.1 | guaA | SAMN05421538_101671 | SAMN05421538_10483 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.978 |
SDD46875.1 | guaB | SAMN05421538_101671 | SAMN05421538_104228 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.944 |
SDD46875.1 | purA | SAMN05421538_101671 | SAMN05421538_10272 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.687 |
SDD83216.1 | SDD46875.1 | SAMN05421538_102537 | SAMN05421538_101671 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.918 |
SDD83216.1 | SDE41549.1 | SAMN05421538_102537 | SAMN05421538_106175 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | GMP synthase-Glutamine amidotransferase. | 0.757 |
SDD83216.1 | guaA | SAMN05421538_102537 | SAMN05421538_10483 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.927 |
SDD83216.1 | guaB | SAMN05421538_102537 | SAMN05421538_104228 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.921 |
SDD83216.1 | purA | SAMN05421538_102537 | SAMN05421538_10272 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.922 |
SDD83216.1 | purH | SAMN05421538_102537 | SAMN05421538_10343 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.922 |