Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pyrCDihydroorotase, multifunctional complex type; Annotation was generated automatically without manual curation. (409 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase; Annotation was generated automatically without manual curation; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 0.999
EDP45842.1
Dihydroorotate dehydrogenase (dihydroorotate oxidase)(dhodehase) (dhodase) (dhod); Catalyzes the conversion of dihydroorotate to orotate.
 
 0.993
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 
 0.960
pyrI
Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase.
    
 0.959
pyrF
Orotidine 5'-phosphate decarboxylase; Annotation was generated automatically without manual curation; Belongs to the OMP decarboxylase family.
 
  
 0.938
nadE
Glutamine-dependent NAD(+) synthetase (NAD(+) synthase[glutamine-hydrolyzing]); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.616
guaA
Gmp synthase [glutamine-hydrolyzing] (glutamineamidotransferase) (gmp synthetase) (gmps); Catalyzes the synthesis of GMP from XMP.
     
 0.606
dapE
Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily.
  
 
 0.584
EDP46098.1
Anhydrase, family 3 protein; Annotation was generated automatically without manual curation.
  
    0.488
EDP45897.1
Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
    
 0.486
Your Current Organism:
Rickettsiella grylli
NCBI taxonomy Id: 59196
Other names: R. grylli
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