Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (780 aa)    
Predicted Functional Partners:
metF
5,10-methylenetetrahydrofolate reductase; Annotation was generated automatically without manual curation; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.985
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
 
 
 0.950
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 0.943
EDP45872.1
Cystathionine gamma-lyase (Gamma-cystathionase)(Probasin-related antigen) (PRB-RA); Annotation was generated automatically without manual curation.
  
 
 0.942
ahcY-2
Adenosylhomocysteinase; Annotation was generated automatically without manual curation.
 
 
 0.905
metK-2
Methionine adenosyltransferase; Annotation was generated automatically without manual curation.
  
 0.892
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
     
 0.826
ptsP
Phosphoenolpyruvate-protein phosphotransferase; Annotation was generated automatically without manual curation; Belongs to the PEP-utilizing enzyme family.
     
  0.777
EDP46952.1
Aspartate kinase, monofunctional class; Annotation was generated automatically without manual curation; Belongs to the aspartokinase family.
   
 
 0.647
adk
Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
      
 0.551
Your Current Organism:
Rickettsiella grylli
NCBI taxonomy Id: 59196
Other names: R. grylli
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