STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purB-2Adenylosuccinate lyase; Annotation was generated automatically without manual curation. (456 aa)    
Predicted Functional Partners:
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 0.975
adk
Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
   
 0.908
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
   
 0.872
surE
5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.870
sucA
Oxoglutarate dehydrogenase (succinyl-transferring), E1 component; Annotation was generated automatically without manual curation.
   
 0.863
icd
Isocitrate dehydrogenase, NADP-dependent; Annotation was generated automatically without manual curation.
    
  0.849
guaA
Gmp synthase [glutamine-hydrolyzing] (glutamineamidotransferase) (gmp synthetase) (gmps); Catalyzes the synthesis of GMP from XMP.
  
 
 0.792
raiA-2
Ribosomal subunit interface protein; Annotation was generated automatically without manual curation.
       0.718
folD
Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
  
 0.664
EDP45979.1
biotin-[acetyl-CoA-carboxylase] ligase; Annotation was generated automatically without manual curation.
  
 
 0.627
Your Current Organism:
Rickettsiella grylli
NCBI taxonomy Id: 59196
Other names: R. grylli
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