ESK65040.1 protein (Abiotrophia defectiva) - STRING interaction network

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Predicted Interactions

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Score

ESK65040.1

Putative neutral zinc metallopeptidase; Psort location: CytoplasmicMembrane, score: 9.46. (228 aa)

Predicted Functional Partners:

ESK65039.1

0.755

ESK65041.1

0.514

ESK65042.1

0.514

ESK65043.1

0.423

ESK65044.1

0.420

Your Current Organism:

Abiotrophia defectiva

NCBI taxonomy Id: 592010
Other names: A. defectiva ATCC 49176, Abiotrophia defectiva ATCC 49176, Abiotrophia defectiva str. ATCC 49176, Abiotrophia defectiva strain ATCC 49176

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ESK65039.1	ESK65040.1	GCWU000182_001582	GCWU000182_001583	Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00.	Putative neutral zinc metallopeptidase; Psort location: CytoplasmicMembrane, score: 9.46.	0.755
ESK65039.1	ESK65041.1	GCWU000182_001582	GCWU000182_001584	Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00.	KEGG: bur:Bcep18194_A3518 5.4e-30 ABC transporter, ATPase subunit K01990; Psort location: CytoplasmicMembrane, score: 9.82.	0.478
ESK65039.1	ESK65042.1	GCWU000182_001582	GCWU000182_001585	Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00.	ABC-2 type transporter; Psort location: CytoplasmicMembrane, score: 10.00.	0.478
ESK65040.1	ESK65039.1	GCWU000182_001583	GCWU000182_001582	Putative neutral zinc metallopeptidase; Psort location: CytoplasmicMembrane, score: 9.46.	Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00.	0.755
ESK65040.1	ESK65041.1	GCWU000182_001583	GCWU000182_001584	Putative neutral zinc metallopeptidase; Psort location: CytoplasmicMembrane, score: 9.46.	KEGG: bur:Bcep18194_A3518 5.4e-30 ABC transporter, ATPase subunit K01990; Psort location: CytoplasmicMembrane, score: 9.82.	0.514
ESK65040.1	ESK65042.1	GCWU000182_001583	GCWU000182_001585	Putative neutral zinc metallopeptidase; Psort location: CytoplasmicMembrane, score: 9.46.	ABC-2 type transporter; Psort location: CytoplasmicMembrane, score: 10.00.	0.514
ESK65040.1	ESK65043.1	GCWU000182_001583	GCWU000182_001586	Putative neutral zinc metallopeptidase; Psort location: CytoplasmicMembrane, score: 9.46.	Histidine kinase; KEGG: spr:spr1815 2.8e-65 hk11; histidine kinase; Psort location: CytoplasmicMembrane, score: 10.00.	0.423
ESK65040.1	ESK65044.1	GCWU000182_001583	GCWU000182_001587	Putative neutral zinc metallopeptidase; Psort location: CytoplasmicMembrane, score: 9.46.	Response regulator receiver domain protein; KEGG: fal:FRAAL4813 1.2e-34 putative two-component system response regulator; Psort location: Cytoplasmic, score: 9.97.	0.420
ESK65041.1	ESK65039.1	GCWU000182_001584	GCWU000182_001582	KEGG: bur:Bcep18194_A3518 5.4e-30 ABC transporter, ATPase subunit K01990; Psort location: CytoplasmicMembrane, score: 9.82.	Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00.	0.478
ESK65041.1	ESK65040.1	GCWU000182_001584	GCWU000182_001583	KEGG: bur:Bcep18194_A3518 5.4e-30 ABC transporter, ATPase subunit K01990; Psort location: CytoplasmicMembrane, score: 9.82.	Putative neutral zinc metallopeptidase; Psort location: CytoplasmicMembrane, score: 9.46.	0.514
ESK65041.1	ESK65042.1	GCWU000182_001584	GCWU000182_001585	KEGG: bur:Bcep18194_A3518 5.4e-30 ABC transporter, ATPase subunit K01990; Psort location: CytoplasmicMembrane, score: 9.82.	ABC-2 type transporter; Psort location: CytoplasmicMembrane, score: 10.00.	0.960
ESK65041.1	ESK65043.1	GCWU000182_001584	GCWU000182_001586	KEGG: bur:Bcep18194_A3518 5.4e-30 ABC transporter, ATPase subunit K01990; Psort location: CytoplasmicMembrane, score: 9.82.	Histidine kinase; KEGG: spr:spr1815 2.8e-65 hk11; histidine kinase; Psort location: CytoplasmicMembrane, score: 10.00.	0.815
ESK65041.1	ESK65044.1	GCWU000182_001584	GCWU000182_001587	KEGG: bur:Bcep18194_A3518 5.4e-30 ABC transporter, ATPase subunit K01990; Psort location: CytoplasmicMembrane, score: 9.82.	Response regulator receiver domain protein; KEGG: fal:FRAAL4813 1.2e-34 putative two-component system response regulator; Psort location: Cytoplasmic, score: 9.97.	0.863
ESK65042.1	ESK65039.1	GCWU000182_001585	GCWU000182_001582	ABC-2 type transporter; Psort location: CytoplasmicMembrane, score: 10.00.	Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00.	0.478
ESK65042.1	ESK65040.1	GCWU000182_001585	GCWU000182_001583	ABC-2 type transporter; Psort location: CytoplasmicMembrane, score: 10.00.	Putative neutral zinc metallopeptidase; Psort location: CytoplasmicMembrane, score: 9.46.	0.514
ESK65042.1	ESK65041.1	GCWU000182_001585	GCWU000182_001584	ABC-2 type transporter; Psort location: CytoplasmicMembrane, score: 10.00.	KEGG: bur:Bcep18194_A3518 5.4e-30 ABC transporter, ATPase subunit K01990; Psort location: CytoplasmicMembrane, score: 9.82.	0.960
ESK65042.1	ESK65043.1	GCWU000182_001585	GCWU000182_001586	ABC-2 type transporter; Psort location: CytoplasmicMembrane, score: 10.00.	Histidine kinase; KEGG: spr:spr1815 2.8e-65 hk11; histidine kinase; Psort location: CytoplasmicMembrane, score: 10.00.	0.901
ESK65042.1	ESK65044.1	GCWU000182_001585	GCWU000182_001587	ABC-2 type transporter; Psort location: CytoplasmicMembrane, score: 10.00.	Response regulator receiver domain protein; KEGG: fal:FRAAL4813 1.2e-34 putative two-component system response regulator; Psort location: Cytoplasmic, score: 9.97.	0.913
ESK65043.1	ESK65040.1	GCWU000182_001586	GCWU000182_001583	Histidine kinase; KEGG: spr:spr1815 2.8e-65 hk11; histidine kinase; Psort location: CytoplasmicMembrane, score: 10.00.	Putative neutral zinc metallopeptidase; Psort location: CytoplasmicMembrane, score: 9.46.	0.423
ESK65043.1	ESK65041.1	GCWU000182_001586	GCWU000182_001584	Histidine kinase; KEGG: spr:spr1815 2.8e-65 hk11; histidine kinase; Psort location: CytoplasmicMembrane, score: 10.00.	KEGG: bur:Bcep18194_A3518 5.4e-30 ABC transporter, ATPase subunit K01990; Psort location: CytoplasmicMembrane, score: 9.82.	0.815

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Network Stats

number of nodes:

4

number of edges:

4

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.334

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006171

cAMP biosynthetic process

5 of 15

2.82

4.89

6.85e-10

GO:0007186

G protein-coupled receptor signaling pathway

11 of 992

1.34

2.32

1.41e-11

GO:0007189

Adenylate cyclase-activating G protein-coupled receptor signaling pathway

5 of 161

1.79

2.24

7.95e-06

GO:0019637

Organophosphate metabolic process

8 of 800

1.3

1.72

5.70e-07

GO:0090407

Organophosphate biosynthetic process

6 of 478

1.4

1.62

2.13e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004016

Adenylate cyclase activity

5 of 13

2.88

5.15

2.49e-10

GO:0046935

1-phosphatidylinositol-3-kinase regulator activity

2 of 22

2.26

0.8

0.0335

GO:0004435

Phosphatidylinositol phospholipase C activity

2 of 22

2.26

0.8

0.0335

GO:0005524

ATP binding

6 of 1712

0.84

0.49

0.0335

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005944

Phosphatidylinositol 3-kinase complex, class IB

3 of 4

3.17

2.97

4.14e-06

GO:0019898

Extrinsic component of membrane

4 of 284

1.45

1.1

0.0028

GO:0005887

Integral component of plasma membrane

5 of 1376

0.86

0.46

0.0462

GO:0005886

Plasma membrane

9 of 5300

0.53

0.36

0.0202

GO:0016020

Membrane

11 of 9165

0.38

0.29

0.0174

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:33911

G alpha (z) signalling events, and G protein alpha subunit, helical insertion

9 of 65

2.44

7.91

9.12e-18

CL:33912

G alpha (z) signalling events, and G-protein alpha subunit, group I

8 of 53

2.48

7.38

3.55e-16

CL:33914

G alpha (z) signalling events, and GAF domain

5 of 42

2.37

4.06

8.08e-09

CL:33917

G alpha (z) signalling events

4 of 27

2.47

3.32

4.33e-07

CL:34008

Phosphoinositide 3-kinase regulatory subunit 5/6, and Positive regulation of Rac protein signal transduction

3 of 5

3.08

3.15

1.82e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

kmr04371

Apelin signaling pathway

11 of 152

2.16

8.02

4.53e-22

kmr04261

Adrenergic signaling in cardiomyocytes

10 of 186

2.03

6.39

2.35e-18

kmr04912

GnRH signaling pathway

7 of 102

2.14

5.19

1.11e-12

kmr04540

Gap junction

7 of 107

2.11

5.12

1.15e-12

kmr04916

Melanogenesis

7 of 123

2.05

4.86

2.35e-12

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-112043

PLC beta mediated events

7 of 59

2.37

5.89

4.39e-13

MAP-112040

G-protein mediated events

7 of 68

2.31

5.71

5.90e-13

MAP-170660

Adenylate cyclase activating pathway

5 of 15

2.82

5.52

4.03e-11

MAP-111885

Opioid Signalling

8 of 119

2.13

5.36

2.75e-13

MAP-397795

G-protein beta:gamma signalling

6 of 53

2.35

5.06

3.71e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005944

Phosphatidylinositol 3-kinase complex, class IB

3 of 7

2.93

2.61

1.71e-05

GOCC:0019898

Extrinsic component of membrane

4 of 142

1.75

1.63

0.00030

GOCC:0016020

Membrane

9 of 4955

0.56

0.38

0.0165

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0456

Lyase

5 of 73

2.13

3.39

7.62e-08

KW-0115

cAMP biosynthesis

3 of 10

2.78

2.9

4.49e-06

KW-0464

Manganese

3 of 73

1.91

1.56

0.00072

KW-0460

Magnesium

3 of 169

1.55

1.06

0.0050

KW-0442

Lipid degradation

2 of 46

1.94

0.96

0.0142

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10486

Phosphoinositide 3-kinase gamma adapter protein p101 subunit

2 of 3

3.12

1.27

0.0052

PF08703

PLC-beta C terminal

2 of 4

3.0

1.27

0.0052

PF06631

Protein of unknown function (DUF1154)

2 of 4

3.0

1.27

0.0052

PF09279

Phosphoinositide-specific phospholipase C, efhand-like

2 of 12

2.52

1.06

0.0118

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029787

Nucleotide cyclase

5 of 29

2.54

3.99

2.16e-08

IPR018297

Adenylyl cyclase class-4/guanylyl cyclase, conserved site

5 of 29

2.54

3.99

2.16e-08

IPR001054

Adenylyl cyclase class-3/4/guanylyl cyclase

5 of 29

2.54

3.99

2.16e-08

IPR009398

Adenylate cyclase, conserved domain

3 of 8

2.87

2.49

2.76e-05

IPR030672

Adenylate cyclase

3 of 11

2.73

2.35

4.87e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00044

Adenylyl- / guanylyl cyclase, catalytic domain

5 of 29

2.54

4.45

2.36e-09

SM00149

Phospholipase C, catalytic domain (part)

2 of 23

2.24

0.85

0.0266

SM00148

Phospholipase C, catalytic domain (part)

2 of 23

2.24

0.85

0.0266

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