STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
KRT35921.1ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (215 aa)    
Predicted Functional Partners:
hisI
KEGG: aco:Amico_0677 6.9e-66 phosphoribosyl-ATP diphosphatase; K11755 phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97; In the N-terminal section; belongs to the PRA-CH family.
 
 
 0.999
KRT35922.1
Hypothetical protein; KEGG: cbe:Cbei_1315 4.4e-32 histidine--tRNA ligase K02502; Psort location: Cytoplasmic, score: 9.97.
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
 0.998
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
 
 0.997
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: aco:Amico_0679 8.5e-45 histidine biosynthesis protein; K01814 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.997
KRT35919.1
KEGG: aco:Amico_0680 4.5e-39 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; K02501 glutamine amidotransferase; Psort location: Cytoplasmic, score: 9.26.
 
  
 0.995
hisB
KEGG: aco:Amico_0681 9.8e-51 imidazoleglycerol-phosphate dehydratase K01693; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.995
hisS
histidine--tRNA ligase; KEGG: aco:Amico_0538 7.6e-147 histidyl-tRNA synthetase K01892; Psort location: Cytoplasmic, score: 10.00.
 0.977
KRT36187.1
Putative histidinol-phosphate transaminase; KEGG: aco:Amico_1039 5.8e-62 aminotransferase class I and II; K00817 histidinol-phosphate aminotransferase; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.922
prs
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.881
Your Current Organism:
Acetomicrobium hydrogeniformans
NCBI taxonomy Id: 592015
Other names: A. hydrogeniformans ATCC BAA-1850, Acetomicrobium hydrogeniformans ATCC BAA-1850, Anaerobaculum hydrogeniforman DSM 22491, Anaerobaculum hydrogeniforman OS1, Anaerobaculum sp. OS1
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