STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT36106.1Protein FolC; KEGG: aco:Amico_0893 1.6e-82 FolC bifunctional protein; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 9.97. (444 aa)    
Predicted Functional Partners:
KRT35677.1
KEGG: dth:DICTH_0461 5.9e-76 dihydropteroate synthase K00796; Psort location: Cytoplasmic, score: 9.97.
 
 0.997
KRT35676.1
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; KEGG: aco:Amico_1446 7.3e-39 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase K00950; Psort location: Cytoplasmic, score: 9.97.
 
 0.942
valS
valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
 
  
 0.918
KRT35001.1
KEGG: ttr:Tter_0579 3.8e-129 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Psort location: Cytoplasmic, score: 9.97.
 
 0.854
clpX
ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
     
 0.716
KRT34999.1
KEGG: gbe:GbCGDNIH1_0765 7.9e-65 dihydropteroate synthase K00796; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.688
guaA
GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.
 
  
 0.648
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.609
glyA-2
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.609
fhs
KEGG: tai:Taci_0816 2.3e-216 formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.605
Your Current Organism:
Acetomicrobium hydrogeniformans
NCBI taxonomy Id: 592015
Other names: A. hydrogeniformans ATCC BAA-1850, Acetomicrobium hydrogeniformans ATCC BAA-1850, Anaerobaculum hydrogeniforman DSM 22491, Anaerobaculum hydrogeniforman OS1, Anaerobaculum sp. OS1
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