STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvDKEGG: afn:Acfer_1425 5.9e-163 dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 9.97; Belongs to the IlvD/Edd family. (533 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.991
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.978
ilvE
Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.971
KRT35506.1
KEGG: hor:Hore_10830 2.5e-148 acetolactate synthase, large subunit, biosynthetic type K01652; Psort location: Cytoplasmic, score: 9.97.
 
 0.967
KRT36350.1
KEGG: aar:Acear_1212 5.5e-112 thiamine pyrophosphate protein TPP binding domain protein; K01652 acetolactate synthase I/II/III large subunit; Psort location: Cytoplasmic, score: 9.97; Belongs to the TPP enzyme family.
 
 0.946
KRT35066.1
Aminotransferase, class IV; KEGG: aco:Amico_1844 8.8e-66 aminotransferase class IV; K00826 branched-chain amino acid aminotransferase; Psort location: Cytoplasmic, score: 9.97.
  
 0.945
KRT35502.1
KEGG: tai:Taci_1607 5.7e-39 acetolactate synthase, small subunit; K01653 acetolactate synthase I/III small subunit; Psort location: Cytoplasmic, score: 9.97.
 
 0.936
KRT35505.1
KEGG: aco:Amico_0098 8.0e-104 3-isopropylmalate dehydrogenase K00052; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.849
KRT35351.1
KEGG: tle:Tlet_1811 1.5e-118 pyridoxal-5'-phosphate-dependent protein beta subunit; K01754 threonine dehydratase; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.805
KRT35301.1
KEGG: tai:Taci_1720 4.0e-93 pyridoxal-5'-phosphate-dependent protein beta subunit; K01754 threonine dehydratase; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.787
Your Current Organism:
Acetomicrobium hydrogeniformans
NCBI taxonomy Id: 592015
Other names: A. hydrogeniformans ATCC BAA-1850, Acetomicrobium hydrogeniformans ATCC BAA-1850, Anaerobaculum hydrogeniforman DSM 22491, Anaerobaculum hydrogeniforman OS1, Anaerobaculum sp. OS1
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