STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (420 aa)    
Predicted Functional Partners:
hisI
KEGG: aco:Amico_0677 6.9e-66 phosphoribosyl-ATP diphosphatase; K11755 phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97; In the N-terminal section; belongs to the PRA-CH family.
 
 0.999
hisB
KEGG: aco:Amico_0681 9.8e-51 imidazoleglycerol-phosphate dehydratase K01693; Psort location: Cytoplasmic, score: 9.97.
 
 0.998
KRT35921.1
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
 
 0.998
KRT36187.1
Putative histidinol-phosphate transaminase; KEGG: aco:Amico_1039 5.8e-62 aminotransferase class I and II; K00817 histidinol-phosphate aminotransferase; Psort location: Cytoplasmic, score: 9.97.
 
 0.996
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.994
hisC
KEGG: tai:Taci_0938 3.7e-106 histidinol-phosphate aminotransferase; K00817 histidinol-phosphate aminotransferase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
 0.989
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: aco:Amico_0679 8.5e-45 histidine biosynthesis protein; K01814 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.988
KRT35919.1
KEGG: aco:Amico_0680 4.5e-39 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; K02501 glutamine amidotransferase; Psort location: Cytoplasmic, score: 9.26.
 
  
 0.980
KRT35414.1
Threonine-phosphate decarboxylase; KEGG: tmt:Tmath_0417 2.4e-134 L-threonine-O-3-phosphate decarboxylase; K04720 threonine-phosphate decarboxylase; Psort location: Cytoplasmic, score: 9.97.
 
 0.974
KRT35406.1
PHP domain protein; KEGG: adg:Adeg_1792 1.0e-119 DNA-directed DNA polymerase K02347; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.915
Your Current Organism:
Acetomicrobium hydrogeniformans
NCBI taxonomy Id: 592015
Other names: A. hydrogeniformans ATCC BAA-1850, Acetomicrobium hydrogeniformans ATCC BAA-1850, Anaerobaculum hydrogeniforman DSM 22491, Anaerobaculum hydrogeniforman OS1, Anaerobaculum sp. OS1
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