STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (425 aa)    
Predicted Functional Partners:
hisC
Putative histidinol-phosphate transaminase; KEGG: cac:CAC3031 3.4e-83 hisC; histidinol-phosphate aminotransferase K00817; Psort location: CytoplasmicMembrane, score: 7.80; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
 0.999
hisB
KEGG: gbe:GbCGDNIH1_2235 2.0e-53 imidazoleglycerol-phosphate dehydratase K01693; Psort location: Cytoplasmic, score: 8.87.
 
 0.999
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
 0.999
hisA
1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; KEGG: oih:OB0548 7.5e-56 phosphoribosyl formimino-5-aminoimidazole isomerase K01814; Psort location: Cytoplasmic, score: 9.98.
 
 0.999
hisF
Putative imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.998
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.996
ESL03833.1
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the Nudix hydrolase family.
 
 
 0.994
ESL03827.1
Hypothetical protein; KEGG: bcz:BCZK1289 7.9e-29 hisZ; histidine--tRNA ligase (histidyl-tRNA synthetase) K02502; Psort location: Cytoplasmic, score: 9.98.
 
  
 0.986
ESL02818.1
Histidinol phosphate phosphatase HisJ family protein; KEGG: oih:OB0554 2.3e-38 histidinol phosphatase K04486; Psort location: Cytoplasmic, score: 8.87; Belongs to the PHP hydrolase family. HisK subfamily.
 
 
 0.946
ESL01675.1
Phosphoribosylformylglycinamidine synthase; KEGG: cac:CAC1655 0. purQ, purL; bifunctional enzyme phosphoribosylformylglycinamidine (FGAM) synthase (synthetase domain/glutamine amidotransferase domain) K01952; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.730
Your Current Organism:
Catonella morbi
NCBI taxonomy Id: 592026
Other names: C. morbi ATCC 51271, Catonella morbi ATCC 51271, Catonella morbi str. ATCC 51271, Catonella morbi strain ATCC 51271
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.