STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (353 aa)    
Predicted Functional Partners:
ispH
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
  
 
 0.975
dxr
1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
 
   
 0.974
ispF
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
 
  
 0.973
ispE
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
  
   
 0.809
rseP
RIP metalloprotease RseP; KEGG: tte:TTE1401 7.3e-65 predicted membrane-associated Zn-dependent protease 1; Psort location: CytoplasmicMembrane, score: 10.00.
       0.805
polC
DNA polymerase III, alpha subunit, Gram-positive type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
       0.805
EEU03681.1
Di-trans,poly-cis-decaprenylcistransferase-like protein; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
  
  
 0.779
cdsA
Phosphatidate cytidylyltransferase; KEGG: tte:TTE1403 1.3e-44 cdsA; CDP-diglyceride synthetase K00981; Psort location: CytoplasmicMembrane, score: 10.00.
     
 0.777
ispD
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; KEGG: sep:SE0319 1.5e-32 putative 4-diphosphocytidyl-2C-methyl-D-erythritol synthase K00991; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.707
EEU03091.1
Putative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; KEGG: sag:SAG1417 3.5e-49 nucleotidyl transferase, putative K00991; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.652
Your Current Organism:
Eubacterium saphenum
NCBI taxonomy Id: 592031
Other names: E. saphenum ATCC 49989, Eubacterium saphenum ATCC 49989, Eubacterium saphenum str. ATCC 49989, Eubacterium saphenum strain ATCC 49989
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.