STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANA30811.1Transcriptional regulator; Activates Salmonella pathogenicity island 4 genes and weakly represses Salmonella pathogenicity island 1 genes; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)    
Predicted Functional Partners:
sirC
Transcriptional regulator SirC; Regulates the expression of the invasion-associated type III secretion system in Salmonella pathogenicity island 1; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.992
appY
Transcriptional regulator HilD; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.831
yopJ
Effector protein YopJ; Involved in the survival of the bacteria in host cells; blocks cytokine production and induces apoptosis; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.636
invF
Transcriptional regulator InvF; Involved in the expression of virulence genes; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.626
spaN
Involved in the surface presentation of antigens needed for the invasion of Salmonella into host cells; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.609
ANA30838.1
ATP synthase; Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells; probable catalytic subunit of a protein translocase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.592
invE
Type III secretion system regulator InvE; Involved in regulation of genes necessary for the entry of Salmonella into host cells; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.587
barA
Histidine kinase; Part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.497
prgH
Type III secretion system needle complex protein PrgH; With InvG, PrgI, and Prg K makes up the membrane spanning needle complex; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.487
gadX
AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.483
Your Current Organism:
Salmonella enterica diarizonae
NCBI taxonomy Id: 59204
Other names: ATCC 43973, CCUG 30040, CIP 82.31, DSM 14847, NCTC 10060, S. enterica subsp. diarizonae, Salmonella cholerae-suis subsp. diarizonae, Salmonella choleraesuis subsp. diarizonae, Salmonella enterica IIIb, Salmonella enterica serovar IIIb, Salmonella enterica subsp. IIIb, Salmonella enterica subsp. Subsp. IIIb, Salmonella enterica subsp. diarizonae
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