Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
frhACoenzyme F420 hydrogenase subunit alpha (frhA). (393 aa)    
Predicted Functional Partners:
frhB
Coenzyme F420-reducing hydrogenase, beta subunit (frhB).
 
 0.999
frhG
Coenzyme F420 hydrogenase subunit gamma (frhG).
 
 0.999
hypA
[NiFe] hydrogenase maturation protein (hypA); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.945
hypF
[NiFe] hydrogenase maturation protein (hypF).
 
 
 
 0.900
hypD
[NiFe] hydrogenase maturation protein (hypD).
 
 
 0.891
hypE
[NiFe] hydrogenase maturation protein (hypE).
 
   
 0.765
mhy2F
Formate hydrogenlyase II subunit F (Mhy2F).
     
0.685
TGAM_0069
7Fe ferredoxin.
  
  
 0.578
hypE-1
Hydrogenase expression/formation related protein (hypE).
 
   
 0.553
TGAM_1236
Conserved hypothetical protein; Belongs to DUF1641 family.
   
 
 0.546
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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