Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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nadENH(3)-dependent NAD synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (254 aa)    
Predicted Functional Partners:
nadM
Nicotinamide-nucleotide adenylyltransferase (nadM).
 
  
 0.957
ppnK
Inorganic polyphosphate/ATP-NAD kinase (poly(P)/ATP NAD kinase) (ppnK); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
  
 0.948
npdA
NAD-dependent protein deacetylase, Sir2 family (npdA); Belongs to the sirtuin family. Class III subfamily.
    
 0.929
dppC
Peptide/nickel transport system permease protein; 6 probable transmembrane helices predicted by modhmm.
 
  
 0.713
dppB
Peptide/nickel transport system permease protein; 6 probable transmembrane helices predicted by modhmm.
 
    0.700
nadC-1
Nicotinate-nucleotide pyrophosphorylase (nadC).
 
  
 0.683
TGAM_0072
Zinc-binding alcohol dehydrogenase.
  
    0.671
TGAM_0331
Solute binding protein, putative; Contains Periplasmic binding protein-like II domain (SSF53850); 2 probable transmembrane helices predicted by modhmm.
 
     0.652
dppD
ABC-type dipeptide/oligopeptide transport system, ATPase component (dppD/oppD).
       0.649
dppF
ABC-type dipeptide/oligopeptide transport system, ATPase component (dppF/oppF).
       0.649
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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