Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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taw3-2Conserved hypothetical protein; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (199 aa)    
Predicted Functional Partners:
taw1
Radical SAM protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
  
  
 0.801
TGAM_0618
DNA helicase, putative.
 
     0.706
TGAM_0154
Conserved hypothetical protein; Belongs to Radical SAM family.
 
     0.664
taw2
Met-10 like-protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).
 
  
 0.649
TGAM_1765
GTP hydrolase, putative; Contains P-loop containing nucleoside triphosphate hydrolase, molybdopterin guanine dinucleotide synthesis protein B and cleavage/polyadenylation factor IA subunit clp1p motives.
  
     0.533
TGAM_0150
P-loop ATPase, MJ1599 type.
 
  
 0.507
top6A
Type II DNA topoisomerase VI, subunit A (Top6A); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family.
  
     0.443
TGAM_1555
ATP-binding protein, putative AAA ATPase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
 
     0.441
TGAM_2067
Met-10 like-protein, putative SAM-dependent methyltransferase.
 
  
 0.440
TGAM_1845
RNA binding protein, containing PUA domain.
 
    0.421
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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