Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
fdh1AFormate dehydrogenase I subunit A (fdh1A). (726 aa)    
Predicted Functional Partners:
fdh1B
Formate dehydrogenase I subunit B (fdh1B).
 
 0.992
mhy2B
Formate hydrogenlyase II subunit B (Mhy2B); Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
  
 0.967
TGAM_0823
7Fe ferredoxin.
  
 0.965
cooS
Carbon monoxide dehydrogenase (cooS).
     
 0.909
fdhA
Formate dehydrogenase alpha subunit (fdhA); 2 probable transmembrane helices predicted by modhmm.
  
  
 
0.907
mhy2A
Formate hydrogenlyase II subunit A (Mhy2A).
  
  
 
0.905
mhy1F
Formate hydrogenlyase I subunit F (Mhy1F).
  
 
 0.836
TGAM_0250
Transcription regulator, TetR family.
 
  
 0.830
mobA
Molybdopterin-guanine dinucleotide biosynthesis protein A (mobA); Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
 
   
 0.708
mhy1G
Formate hydrogenlyase I subunit G (Mhy1G).
  
  
 0.676
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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