Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene fusion
Co-occurrence
Co-expression
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[Homology]
Score
hypE[NiFe] hydrogenase maturation protein (hypE). (338 aa)    
Predicted Functional Partners:
hypD
[NiFe] hydrogenase maturation protein (hypD).
 
 
 0.998
hypF
[NiFe] hydrogenase maturation protein (hypF).
 
 
 0.990
hypC-2
[NiFe] hydrogenase maturation protein (hypC).
 
 
 0.986
TGAM_0258
Nucleotidyltransferase.
       0.914
TGAM_0259
Conserved hypothetical protein; Contains DUF103 domain and Nucleotidyltransferase substrate binding subunit/domain.
       0.914
hypC-1
[NiFe] hydrogenase maturation protein (hypC).
 
 
 0.816
hypA
[NiFe] hydrogenase maturation protein (hypA); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.804
TGAM_0256
Conserved hypothetical protein.
       0.803
TGAM_0257
Nucleotide binding protein, putative, containing PIN domain.
       0.773
frhA
Coenzyme F420 hydrogenase subunit alpha (frhA).
 
   
 0.765
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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