Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
speHS-adenosylmethionine decarboxylase proenzyme (speH); Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (143 aa)    
Predicted Functional Partners:
speE
Spermidine synthase (speE); Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family.
 
 0.999
mat
S-adenosylmethionine synthetase (mat); Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family.
  
  
 0.914
secD
Protein-export membrane protein (secD); Involved in protein export.
  
    0.795
secDF
Protein export membrane protein, SecD/SecF family (secDF); Involved in protein export.
  
    0.782
trkA
Trk system potassium uptake protein trkA-like protein (trkA).
     
 0.753
atpH
Archaeal/vacuolar-type H+-ATPase subunit H (atpH).
       0.559
atpI
Archaeal/vacuolar-type H+-ATPase subunit I (atpI); 7 probable transmembrane helices predicted by modhmm; Belongs to the V-ATPase 116 kDa subunit family.
       0.559
atpK
Archaeal/vacuolar-type H+-ATPase, subunit K (atpK); 4 probable transmembrane helices predicted by modhmm.
       0.542
pdaD
Pyruvoyl-dependent arginine decarboxylase (pdaD/PvlArgDC); Belongs to the PdaD family.
 
  
 0.525
atpE
Archaeal/vacuolar-type H+-ATPase, subunit E (atpE); Produces ATP from ADP in the presence of a proton gradient across the membrane.
       0.457
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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