node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TGAM_0526 | TGAM_1854 | TGAM_0526 | TGAM_1854 | Diphthamide synthesis DPH2 protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | ATP-binding protein, PP-loop superfamily. | 0.494 |
TGAM_0526 | dph5 | TGAM_0526 | TGAM_0314 | Diphthamide synthesis DPH2 protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase (Diphtamide biosynthesis methyltransferase) (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.882 |
TGAM_0526 | eRF1 | TGAM_0526 | TGAM_0692 | Diphthamide synthesis DPH2 protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Peptide chain release factor eRF/aRF, subunit 1 (eRF1/prf1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | 0.416 |
TGAM_0526 | eif2b | TGAM_0526 | TGAM_2025 | Diphthamide synthesis DPH2 protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation initiation factor 2 beta subunit (eif2b); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.586 |
TGAM_0526 | fusA | TGAM_0526 | TGAM_1397 | Diphthamide synthesis DPH2 protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation elongation factor EF-2 (fusA); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. E [...] | 0.970 |
TGAM_0526 | rps4E | TGAM_0526 | TGAM_1990 | Diphthamide synthesis DPH2 protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | SSU ribosomal protein S4E (rps4E); Belongs to the eukaryotic ribosomal protein eS4 family. | 0.614 |
TGAM_0925 | dph5 | TGAM_0925 | TGAM_0314 | Met-10 like-protein, putative SAM-dependent methyltransferase. | Diphthine synthase (Diphtamide biosynthesis methyltransferase) (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.590 |
TGAM_0925 | eRF1 | TGAM_0925 | TGAM_0692 | Met-10 like-protein, putative SAM-dependent methyltransferase. | Peptide chain release factor eRF/aRF, subunit 1 (eRF1/prf1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | 0.513 |
TGAM_0925 | eif2b | TGAM_0925 | TGAM_2025 | Met-10 like-protein, putative SAM-dependent methyltransferase. | Translation initiation factor 2 beta subunit (eif2b); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.543 |
TGAM_1854 | TGAM_0526 | TGAM_1854 | TGAM_0526 | ATP-binding protein, PP-loop superfamily. | Diphthamide synthesis DPH2 protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.494 |
TGAM_1854 | dph5 | TGAM_1854 | TGAM_0314 | ATP-binding protein, PP-loop superfamily. | Diphthine synthase (Diphtamide biosynthesis methyltransferase) (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.804 |
TGAM_1854 | eif2b | TGAM_1854 | TGAM_2025 | ATP-binding protein, PP-loop superfamily. | Translation initiation factor 2 beta subunit (eif2b); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.405 |
TGAM_1854 | fusA | TGAM_1854 | TGAM_1397 | ATP-binding protein, PP-loop superfamily. | Translation elongation factor EF-2 (fusA); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. E [...] | 0.707 |
dph5 | TGAM_0526 | TGAM_0314 | TGAM_0526 | Diphthine synthase (Diphtamide biosynthesis methyltransferase) (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | Diphthamide synthesis DPH2 protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.882 |
dph5 | TGAM_0925 | TGAM_0314 | TGAM_0925 | Diphthine synthase (Diphtamide biosynthesis methyltransferase) (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | Met-10 like-protein, putative SAM-dependent methyltransferase. | 0.590 |
dph5 | TGAM_1854 | TGAM_0314 | TGAM_1854 | Diphthine synthase (Diphtamide biosynthesis methyltransferase) (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | ATP-binding protein, PP-loop superfamily. | 0.804 |
dph5 | eRF1 | TGAM_0314 | TGAM_0692 | Diphthine synthase (Diphtamide biosynthesis methyltransferase) (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | Peptide chain release factor eRF/aRF, subunit 1 (eRF1/prf1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | 0.592 |
dph5 | eif2b | TGAM_0314 | TGAM_2025 | Diphthine synthase (Diphtamide biosynthesis methyltransferase) (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | Translation initiation factor 2 beta subunit (eif2b); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.660 |
dph5 | fusA | TGAM_0314 | TGAM_1397 | Diphthine synthase (Diphtamide biosynthesis methyltransferase) (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | Translation elongation factor EF-2 (fusA); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. E [...] | 0.999 |
dph5 | rps4E | TGAM_0314 | TGAM_1990 | Diphthine synthase (Diphtamide biosynthesis methyltransferase) (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | SSU ribosomal protein S4E (rps4E); Belongs to the eukaryotic ribosomal protein eS4 family. | 0.632 |